Miotto MC, Weninger G, Dridi H, Yuan Q, Liu Y, Wronska A, Melville Z, Sittenfeld L, Reiken S, Marks AR
Sci Adv (2022) 8 pp. eabo1272-eabo1272 [ DOI: doi:10.1126/sciadv.abo1272 Pubmed: 35857850 ]
Human KCNQ2-CaM in complex with QO-83
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8xo1
Q-score: 0.233
To Be Published
- ~{n}-[2-azanyl-3-fluoranyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-3-cyclopentyl-propanamide (423 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (95 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with qo-83 (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 9cui
Q-score: 0.468
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Ancestral htrpv6 tetramer in complex with calmodulin (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Structure of human full-length derived TRPV6 channel in Calmodulin-bound state
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 9cuk
Q-score: 0.482
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Derived htrpv6 tetramer in complex with calmodulin (370 kDa, Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Structure of chimeric RyR complex with flubendiamide
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8xji
Q-score: 0.34
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Chimeric ryr ca2+/atp/caffeine/cam1234/flu (2 MDa, Complex from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Flubendiamide (682 Da, Ligand)
Structure of chimeric RyR Complex with tetraniliprole
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8xkh
Q-score: 0.326
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Tetraniliprole (544 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Chimeric ryr ca2+/atp/caffeine/cam1234/tet (2 MDa, Complex from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlf
Q-score: 0.375
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chimeric ryr ca2+/atp/caffeine/cam1234 (Complex from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8xlh
Q-score: 0.386
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Chimeric ryr-c4657m/g4819e ca2+/atp/caffeine/cam1234 (2 MDa, Complex from Oryctolagus cuniculus)
- Caffeine (194 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of chimeric RyR-I4657M/G4819E complex with chlorantraniliprole
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8y40
Q-score: 0.306
Lin L, Wang C, Wang W, Jiang H, Murayama T, Kobayashi T, Hadiatullah H, Chen YS, Wu S, Wang Y, Korza H, Gu Y, Zhang Y, Du J, Van Petegem F, Yuchi Z
Nat Commun (2024) 15 pp. 9056-9056 [ Pubmed: 39428398 DOI: doi:10.1038/s41467-024-53490-0 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Chimeric ryr-i4657m/g4819e ca2+/atp/caffeine/cam1234/chl (2 MDa, Complex from Oryctolagus cuniculus)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryanodine receptor 1 (565 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
- 5-bromanyl-n-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide (483 Da, Ligand)
- Calcium ion (40 Da, Ligand)
PhK holoenzyme in inactive state, muscle isoform
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jfk
Q-score: 0.265
Yang X, Zhu M, Lu X, Wang Y, Xiao J
Nat Commun (2024) 15 pp. 2719-2719 [ DOI: doi:10.1038/s41467-024-47049-2 Pubmed: 38548794 ]
- Phosphorylase b kinase regulatory subunit beta (125 kDa, Protein from Homo sapiens)
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (45 kDa, Protein from Homo sapiens)
- Farnesyl (206 Da, Ligand)
- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (137 kDa, Protein from Homo sapiens)
- Phosphorylase b kinase, muscle isoform (Complex from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)