HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tq1
Q-score: 0.512
Altman PX, Ozorowski G, Stanfield RL, Haakenson J, Appel M, Parren M, Lee WH, Sang H, Woehl J, Saye-Francisco K, Sewall LM, Joyce C, Song G, Porter K, Landais E, Andrabi R, Wilson IA, Ward AB, Mwangi W, Smider VV, Burton DR, Sok D
PLoS Pathog (2024) 20 pp. e1012042-e1012042 [ DOI: doi:10.1371/journal.ppat.1012042 Pubmed: 39250525 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nhp rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bovine bess4 fab heavy chain (17 kDa, Protein from Bos taurus)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Nhp rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv-1 bg505 sosip env in complex with bovine bess4 fab and nhp rm20a3 fab (Complex from Human immunodeficiency virus 1)
Cryo-EM structure of llama J3 VHH antibody in complex with HIV-1 Env BG505 DS-SOSIP.664
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7lpn
Q-score: 0.465
Zhou T, Chen L, Gorman J, Wang S, Kwon YD, Lin BC, Louder MK, Rawi R, Stancofski ED, Yang Y, Zhang B, Quigley AF, McCoy LE, Rutten L, Verrips T, Weiss RA, Doria-Rose NA, Shapiro L, Kwong PD
Structure (2022) 30 pp. 862-875.e4 [ Pubmed: 35413243 DOI: doi:10.1016/j.str.2022.03.012 ]
- Hiv-1 env with llama j3 vhh (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- J3 vhh (14 kDa, Protein from Lama glama)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of HIV-1 Env trimer BG505 SOSIP.664 in complex with CD4bs antibody Ab1573
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7tfo
Q-score: 0.359
Yang Z, Dam KA, Bridges MD, Hoffmann MAG, DeLaitsch AT, Gristick HB, Escolano A, Gautam R, Martin MA, Nussenzweig MC, Hubbell WL, Bjorkman PJ
Nat Commun (2022) 13 pp. 732-732 [ DOI: doi:10.1038/s41467-022-28424-3 Pubmed: 35136084 ]
- Envelope glycoprotein bg505 sosip.664 - gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein bg505 sosip.664 - gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cd4 binding site antibody ab1573 - fab light chain (23 kDa, Protein from Macaca mulatta)
- Bg505 sosip.664 in complex with cd4bs antibody ab1573 (Complex from Macaca mulatta)
- Cd4 binding site antibody ab1573 - fab heavy chain (24 kDa, Protein from Macaca mulatta)
Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7tfn
Q-score: 0.437
Yang Z, Dam KA, Bridges MD, Hoffmann MAG, DeLaitsch AT, Gristick HB, Escolano A, Gautam R, Martin MA, Nussenzweig MC, Hubbell WL, Bjorkman PJ
Nat Commun (2022) 13 pp. 732-732 [ DOI: doi:10.1038/s41467-022-28424-3 Pubmed: 35136084 ]
- Envelope glycoprotein bg505 sosip.664 - gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Anti-hiv-1 cd4bs antibody fab ab1303 - heavy chain (25 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein bg505 sosip.664 - gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cd4 binding site antibody fab ab1303 - light chain (23 kDa, Protein from Macaca mulatta)
- Cryo-em map of ab1303 in complex with bg505 sosip.664 env trimer (local resolution refined) (Complex from Human immunodeficiency virus 1)
- Alpha-d-mannopyranose (180 Da, Ligand)
Cryo-EM structure of M4008_N1 Fab in complex with BG505 DS-SOSIP.664 Env trimer
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7rai
Q-score: 0.529
Chan KW, Luo CC, Lu H, Wu X, Kong XP
Nat Commun (2021) 12 pp. 6464-6464 [ Pubmed: 34753944 DOI: doi:10.1038/s41467-021-26846-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- M4008_n1 fab heavy chain (28 kDa, Protein from Homo sapiens)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- M4008_n1 fab in complex with bg505 ds-sosip.664 env trimer (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- M4008_n1 fab light chain (23 kDa, Protein from Homo sapiens)
Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7mxe
Q-score: 0.492
Abernathy ME, Gristick HB, Vielmetter J, Keeffe JR, Gnanapragasam PNP, Lee YE, Escolano A, Gautam R, Seaman MS, Martin MA, Nussenzweig MC, Bjorkman PJ
NPJ Vaccines (2021) 6 pp. 126-126 [ DOI: doi:10.1038/s41541-021-00387-4 Pubmed: 34697307 ]
- Ab1245 fab (Complex from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein bg505 sosip.664 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Ab1245 fab heavy chain (28 kDa, Protein from Macaca mulatta)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 8anc195 g52k5 fab light chain (23 kDa, Protein from Homo sapiens)
- Ab1245 fab light chain (25 kDa, Protein from Macaca mulatta)
- Complex of nhp-isolated ab1245 fab and bnab 8anc195 g52k5 fab bound to bg505 sosip.664 trimer (500 kDa, Complex)
- 8anc195 g52k5 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 8anc195 g52k5 fab (Complex from Homo sapiens)
Structure of CD4 mimetic BNM-III-170 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7lo6
Q-score: 0.456
Jette CA, Barnes CO, Kirk SM, Melillo B, Smith III AB, Bjorkman PJ
Nat Commun (2021) 12 pp. 1950-1950 [ DOI: doi:10.1038/s41467-021-21816-x Pubmed: 33782388 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- ~{n}'-[(1~{r},2~{r})-2-(carbamimidamidomethyl)-5-(methylaminomethyl)-2,3-dihydro-1~{h}-inden-1-yl]-~{n}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide (446 Da, Ligand)
- Envelope glycoprotein bg505 sosip.664 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 17b fab light chain (23 kDa, Protein from Homo sapiens)
- Bg505 sosip.664 hiv-1 env trimer (Complex from Human immunodeficiency virus 1)
- 17b fab heavy chain (25 kDa, Protein from Homo sapiens)
- Complex of bg505 sosip.664 env with cd4 mimetic bnm-iii-170 and 17b fab (Complex)
- 17b fab (Complex from Homo sapiens)
HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in HEK293F cells in complex with RM20A3 Fab
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6x9r
Q-score: 0.551
Berndsen ZT, Chakraborty S, Wang X, Cottrell CA, Torres JL, Diedrich JK, Lopez CA, Yates 3rd JR, van Gils MJ, Paulson JC, Gnanakaran S, Ward AB
PNAS (2020) 117 pp. 28014-28025 [ Pubmed: 33093196 DOI: doi:10.1073/pnas.2000260117 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 envelope glycoprotein bg505 sosip.664 expressed in hek293f cells in complex with rm20a3 fab (Complex)
- Rm20a3 fab (Complex from Macaca mulatta)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 (Complex from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in stable CHO cells in complex with RM20A3 Fab
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6x9s
Q-score: 0.547
Berndsen ZT, Chakraborty S, Wang X, Cottrell CA, Torres JL, Diedrich JK, Lopez CA, Yates 3rd JR, van Gils MJ, Paulson JC, Gnanakaran S, Ward AB
PNAS (2020) 117 pp. 28014-28025 [ Pubmed: 33093196 DOI: doi:10.1073/pnas.2000260117 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 envelope glycoprotein bg505 sosip.664 expressed in stable cho cells in complex with rm20a3 fab (Complex)
- Rm20a3 fab (Complex from Macaca mulatta)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 (Complex from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in HEK293S cells in complex with RM20A3 Fab
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6x9t
Q-score: 0.545
Berndsen ZT, Chakraborty S, Wang X, Cottrell CA, Torres JL, Diedrich JK, Lopez CA, Yates 3rd JR, van Gils MJ, Paulson JC, Gnanakaran S, Ward AB
PNAS (2020) 117 pp. 28014-28025 [ Pubmed: 33093196 DOI: doi:10.1073/pnas.2000260117 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 envelope glycoprotein bg505 sosip.664 expressed in hek293s cells in complex with rm20a3 fab (Complex)
- Rm20a3 fab (Complex from Macaca mulatta)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 (Complex from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)