Paired helical tau filaments in dominantly inherited Alzheimer disease with cotton wool plaques
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 9czi
Q-score: 0.588
Hoq MR, Fernandez A, Vago FS, Hallinan GI, Bharath SR, Li D, Ozcan KA, Garringer HJ, Jiang W, Vidal R, Ghetti B
Acta Neuropathol (2024) 148 pp. 20-20 [ Pubmed: 39147931 DOI: doi:10.1007/s00401-024-02786-y ]
- Microtubule-associated protein tau (7 kDa, Protein from Homo sapiens)
- Paired helical tau filament (Tissue from Homo sapiens)
P301T type II tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
PHF type tau filament from V337M mutant
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eo9
Q-score: 0.486
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.04.29.591661 Pubmed: 38746388 ]
PHF type tau filament from R406W mutant
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eog
Q-score: 0.573
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.04.29.591661 Pubmed: 38746388 ]
- Phf tau filament from mutant r406w (Complex from Homo sapiens)
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
Type IIIa beta-amyloid 40 Filaments from Down syndrome
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8sek
Q-score: 0.481
Fernandez A, Hoq MR, Hallinan GI, Li D, Bharath SR, Vago FS, Zhang X, Ozcan KA, Newell KL, Garringer HJ, Jiang W, Ghetti B, Vidal R
Nat Struct Mol Biol (2024) 31 pp. 903-909 [ DOI: doi:10.1038/s41594-024-01252-3 Pubmed: 38553642 ]
- Type iiib beta-amyloid 40 filament (4 kDa, Protein from Homo sapiens)
- Type iiia beta amyloid 40 (Tissue from Homo sapiens)
doublet TMEM106B type 1 filament - individual 4, prefrontal cortex
Tetter S, Arseni D, Murzin AG, Buhidma Y, Peak-Chew SY, Garringer HJ, Newell KL, Vidal R, Apostolova LG, Lashley T, Ghetti B, Ryskeldi-Falcon B
Nature (2024) 625 pp. 345-351 [ DOI: doi:10.1038/s41586-023-06801-2 Pubmed: 38057661 ]
Alpha-synuclein filament assembled in vitro with mutant (7 residues insertion) protein
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
WT alpha-synuclein filament assembled in vitro
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Structure of Type I Prion filaments from Gerstmann-Straussler-Scheinker disease
Resolution: 3.29 Å
EM Method: Helical reconstruction
Fitted PDBs: 7umq
Q-score: 0.481
Hallinan GI, Ozcan KA, Hoq MR, Cracco L, Vago FS, Bharath SR, Li D, Jacobsen M, Doud EH, Mosley AL, Fernandez A, Garringer HJ, Jiang W, Ghetti B, Vidal R
Acta Neuropathol (2022) 144 pp. 509-520 [ Pubmed: 35819518 DOI: doi:10.1007/s00401-022-02461-0 ]
Structure of Type II Prion filaments from Gerstmann-Straussler-Scheinker disease
Resolution: 3.13 Å
EM Method: Helical reconstruction
Fitted PDBs: 7un5
Q-score: 0.544
Hallinan GI, Ozcan KA, Hoq MR, Cracco L, Vago FS, Bharath SR, Li D, Jacobsen M, Doud EH, Mosley AL, Fernandez A, Garringer HJ, Jiang W, Ghetti B, Vidal R
Acta Neuropathol (2022) 144 pp. 509-520 [ Pubmed: 35819518 DOI: doi:10.1007/s00401-022-02461-0 ]