P301L tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type I tau filaments from human brain
Resolution: 2.26 Å
EM Method: Helical reconstruction
Fitted PDBs: 9gg1
Q-score: 0.69
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type II tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
PHF type tau filament from V337M mutant
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eo7
Q-score: 0.568
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.04.29.591661 Pubmed: 38746388 ]
- Tau filament v337m (Complex from Homo sapiens)
- Isoform tau-f of microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
PHF type tau filament from V337M mutant
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eo9
Q-score: 0.486
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.04.29.591661 Pubmed: 38746388 ]
PHF type tau filament from V337M mutant
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eoe
Q-score: 0.641
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.04.29.591661 Pubmed: 38746388 ]
PHF type tau filament from R406W mutant
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eog
Q-score: 0.573
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.04.29.591661 Pubmed: 38746388 ]
- Phf tau filament from mutant r406w (Complex from Homo sapiens)
- Microtubule-associated protein tau (45 kDa, Protein from Homo sapiens)
PHF type tau filament from in vitro V337M mutant
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 9eoh
Q-score: 0.572
Qi C, Lovestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.04.29.591661 Pubmed: 38746388 ]
Type IIIa beta-amyloid 40 Filaments from Down syndrome
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8sek
Q-score: 0.481
Fernandez A, Hoq MR, Hallinan GI, Li D, Bharath SR, Vago FS, Zhang X, Ozcan KA, Newell KL, Garringer HJ, Jiang W, Ghetti B, Vidal R
Nat Struct Mol Biol (2024) 31 pp. 903-909 [ DOI: doi:10.1038/s41594-024-01252-3 Pubmed: 38553642 ]
- Type iiib beta-amyloid 40 filament (4 kDa, Protein from Homo sapiens)
- Type iiia beta amyloid 40 (Tissue from Homo sapiens)
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]