Structure of the human endogenous PCNA-FEN1 complex - State A
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8yjh
Q-score: 0.421
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Endogenous state a pcna-dna-fen1 complex (Complex from Homo sapiens)
- Downstream dna chain f (3 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- 5 prime dna (867 Da, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Upstream dna chain j (4 kDa, DNA from Homo sapiens)
- Parent strand chain e (7 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State B
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjl
Q-score: 0.448
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Upstream dna (5 kDa, DNA from Homo sapiens)
- Parent strand (8 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- 5 prime dna (867 Da, DNA from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Endogenous state b pcna-dna-fen1 complex (Complex from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State C
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjq
Q-score: 0.441
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Endogenous state c pcna-dna-fen1 complex (Complex from Homo sapiens)
- Upstream dna (5 kDa, DNA from Homo sapiens)
- 5 prime flap dna (1 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent strand (8 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State D
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjr
Q-score: 0.423
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state d pcna-dna-fen1 complex (Complex from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent dna (9 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State E
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8yjs
Q-score: 0.443
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Endogenous state e pcna-dna-fen1 complex (Complex from Homo sapiens)
- Parent strand dna (8 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Upstream dna (5 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State F
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8yju
Q-score: 0.399
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state f pcna-dna-fen1 complex (Complex from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State G
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjv
Q-score: 0.447
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Upstream dna (6 kDa, DNA from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Endogenous state g pcna-dna-fen1 complex (Complex from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sa)
Structure of the human endogenous PCNA-FEN1 complex - State H
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Endogenous state h pcna-dna-fen1 complex (Complex from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1-RNase H2 complex - State D
Resolution: 5.15 Å
EM Method: Single-particle
Fitted PDBs: 8yjz
Q-score: 0.302
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Ribonuclease h2 subunit b (35 kDa, Protein from Homo sapiens)
- Ribonuclease h2 subunit c (17 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (4 kDa, DNA from Homo sapiens)
- Ribonuclease h2 subunit a (33 kDa, Protein from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state d pcna-dna-fen1-rnase h2 complex (Complex from Homo sapiens)
complex of DNA ligase I and FEN1 on PCNA and DNA
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7qo1
Q-score: 0.303
Blair K, Tehseen M, Raducanu VS, Shahid T, Lancey C, Rashid F, Creuhet R, Hamdan SM, De Biasio A
Nat Commun (2022) 13 pp. 7833-7833 [ Pubmed: 36539424 DOI: doi:10.1038/s41467-022-35475-z ]
- Complex of dna ligase i and fen1 on pcna and dna (Complex from Homo sapiens)
- Adenosine monophosphate (347 Da, Ligand)
- Proliferating cell nuclear antigen (29 kDa, Protein from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Oligo19ddc (5 kDa, DNA from synthetic construct)
- Oligo32 (9 kDa, DNA from synthetic construct)
- Dna ligase 1 (84 kDa, Protein from Homo sapiens)
- Oligo13p (3 kDa, DNA from synthetic construct)