Hemagglutinin H1 New Caledonia 1999 in complex with monoclonal antibody Fab 43_S0008
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 9b2m
Q-score: 0.377
Ataca S, Sangesland M, de Paiva Froes Rocha R, Torrents de la Pena A, Ronsard L, Boyoglu-Barnum S, Gillespie RA, Tsybovsky Y, Stephens T, Moin SM, Lederhofer J, Creanga A, Andrews SF, Barnes RM, Rohrer D, Lonberg N, Graham BS, Ward AB, Lingwood D, Kanekiyo M
Cell Rep (2024) 43 pp. 114990-114990 [ DOI: doi:10.1016/j.celrep.2024.114990 Pubmed: 39580804 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain monoclonal antibody fab 3_s0008 (24 kDa, Protein from Mus sp.)
- Hemagglutinin ha1 chain (37 kDa, Protein from Influenza A virus)
- Heavy chain monoclonal antibody fab 3_s0008 (24 kDa, Protein from Mus sp.)
- Hemagglutinin h1 new caledonia 1999 in complex with monoclonal antibody fab 43_s0008 (330 kDa, Complex from Homo sapiens)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8ur5
Q-score: 0.429
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP
Cell Rep (2023) 42 pp. 113552-113552 [ Pubmed: 38096058 DOI: doi:10.1016/j.celrep.2023.113552 ]
- I53_dn5 nanoparticle displaying the trimeric ha heads with heptad domain, th-1heptad-i53_dn5 (local refinement of th-1heptad) (Complex)
- Trimer head ha (Complex from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Trimer head ha,hemagglutinin ha1 chain (44 kDa, Protein from synthetic construct)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8ur7
Q-score: 0.403
Ellis D, Dosey A, Boyoglu-Barnum S, Park YJ, Gillespie R, Syeda H, Hutchinson GB, Tsybovsky Y, Murphy M, Pettie D, Matheson N, Chan S, Ueda G, Fallas JA, Carter L, Graham BS, Veesler D, Kanekiyo M, King NP
Cell Rep (2023) 42 pp. 113552-113552 [ Pubmed: 38096058 DOI: doi:10.1016/j.celrep.2023.113552 ]
- I53_dn5 nanoparticle displaying the trimeric ha heads with heptad domain, th-6heptad-i53_dn5 (Complex)
- Trimer head ha,hemagglutinin ha1 chain (48 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pentamer (Complex from synthetic construct)
- Trimer head ha (Complex from synthetic construct)
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 8d21
Q-score: 0.395
Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA, Gorman J, Raab JE, Brand J, Creanga A, Gajjala SR, Narpala S, Cheung CSF, Harris DR, Zhou T, Gordon I, Holman L, Mendoza F, Houser KV, Chen GL, Mascola JR, Graham BS, Kwong PD, Widge A, Dropulic LK, Ledgerwood JE, Kanekiyo M, McDermott AB
Sci Transl Med (2023) 15 pp. eade4976-eade4976 [ DOI: doi:10.1126/scitranslmed.ade4976 Pubmed: 37075126 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1b06 light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em structure of the vrc321 clinical trial, vaccine-elicited, human antibody 1b06 in complex with a stabilized nc99 ha trimer (Complex)
- 1b06 fab with nc99 ha trimer (Complex from Influenza A virus)
- 1b06 heavy chain (13 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7l0l
Q-score: 0.555
Andrews SF, Raab JE, Gorman J, Gillespie RA, Cheung CSF, Rawi R, Cominsky LY, Boyington JC, Creanga A, Shen CH, Harris DR, Olia AS, Nazzari AF, Zhou T, Houser KV, Chen GL, Mascola JR, Graham BS, Kanekiyo M, Ledgerwood JE, Kwong PD, McDermott AB
Nat Med (2022) 28 pp. 373-382 [ DOI: doi:10.1038/s41591-021-01636-8 Pubmed: 35115707 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 316-310-1b11 heavy chain (25 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (38 kDa, Protein from Influenza A virus (A/Canada/720/2005(H2N2)))
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus (A/Canada/720/2005(H2N2)))
- 316-310-1b11 fab in complex with an h2 can05 ha trimer (Complex from Influenza A virus)
- 316-310-1b11 light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7mfg
Q-score: 0.411
Andrews SF, Raab JE, Gorman J, Gillespie RA, Cheung CSF, Rawi R, Cominsky LY, Boyington JC, Creanga A, Shen CH, Harris DR, Olia AS, Nazzari AF, Zhou T, Houser KV, Chen GL, Mascola JR, Graham BS, Kanekiyo M, Ledgerwood JE, Kwong PD, McDermott AB
Nat Med (2022) 28 pp. 373-382 [ DOI: doi:10.1038/s41591-021-01636-8 Pubmed: 35115707 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 310-030-1d06 fab in complex with an h1 nc99 ha trimer (Complex from Influenza A virus)
- 310-030-1d06 light (11 kDa, Protein from Homo sapiens)
- 310-030-1d06 heavy (13 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus)
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 6xsk
Q-score: 0.406
Moin SM, Boyington JC, Boyoglu-Barnum S, Gillespie RA, Cerutti G, Cheung CS, Cagigi A, Gallagher JR, Brand J, Prabhakaran M, Tsybovsky Y, Stephens T, Fisher BE, Creanga A, Ataca S, Rawi R, Corbett KS, Crank MC, Karlsson Hedestam GB, Gorman J, McDermott AB, Harris AK, Zhou T, Kwong PD, Shapiro L, Mascola JR, Graham BS, Kanekiyo M
Immunity (2022) 55 pp. 2405-2418.e7 [ DOI: doi:10.1016/j.immuni.2022.10.015 Pubmed: 36356572 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 789-203-3c12 fab heavy and light chains (Cellular component from Macaca mulatta)
- Influenza hemagglutinin (Cellular component from Influenza A virus (A/Solomon Islands/3/2006(H1N1)))
- 789-203-3c12 fab heavy chain (49 kDa, Protein from Macaca mulatta)
- 789-203-3c12 fab light chain (23 kDa, Protein from Macaca mulatta)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus (A/Solomon Islands/3/2006(H1N1)))
- Hemagglutinin ha1 chain (38 kDa, Protein from Influenza A virus (A/Solomon Islands/3/2006(H1N1)))
- Influenza hemagglutinin si06 trimer in complex with 789-203-3c12 fab (Cellular component)
Cryo-EM structure of SRR2899884.46167H+MEDI8852L fab in complex with Victoria HA
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 7kc1
Q-score: 0.461
Chuang GY, Shen CH, Cheung CS, Gorman J, Creanga A, Joyce MG, Leung K, Rawi R, Wang L, Yang ES, Yang Y, Zhang B, Zhang Y, Kanekiyo M, Zhou T, DeKosky BJ, Graham BS, Mascola JR, Kwong PD
Front Immunol (2021) 12 pp. 662909-662909 [ DOI: doi:10.3389/fimmu.2021.662909 Pubmed: 34135892 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab light chain (22 kDa, Protein from Homo sapiens)
- Hemagglutinin (38 kDa, Protein from Influenza A virus)
- Fab heavy chain (24 kDa, Protein from Homo sapiens)
- Fusion protein of hemagglutinin and envelope glycoprotein (25 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of srr2899884.46167h+medi8852l fab in complex with victoria ha (Complex from Influenza A virus)
- Cryo-em structure of srr2899884.46167h+medi8852l fab in complex with victoria ha (Complex)
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M
Nature (2021) 592 pp. 623-628 [ Pubmed: 33762730 DOI: doi:10.1038/s41586-021-03365-x ]
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M
Nature (2021) 592 pp. 623-628 [ Pubmed: 33762730 DOI: doi:10.1038/s41586-021-03365-x ]