Cryo-EM structure of the SFV009 3G01 Fab in complex with A/California/04/2009
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9dm0
Q-score: 0.511
Lin TH, Lee CD, Fernandez-Quintero ML, Ferguson JA, Han J, Zhu X, Yu W, Guthmiller JJ, Krammer F, Wilson PC, Ward AB, Wilson IA
Nat Commun (2025) 16 pp. 1268-1268 [ DOI: doi:10.1038/s41467-025-56496-4 Pubmed: 39894881 ]
- Hemagglutinin ca09 homotrimer bound to anchor fab (Complex from Homo sapiens)
- Hemagglutinin ha1/2 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab heavy chain (13 kDa, Protein from Homo sapiens)
- Fab light chain (11 kDa, Protein from Homo sapiens)
- Hemagglutinin (26 kDa, Protein from Influenza A virus (A/California/04/2009(H1N1)))
- Fab (Complex)
- Hemagglutinin (35 kDa, Protein from Influenza A virus (A/California/04/2009(H1N1)))
Influenza A virus Hemagglutinin H5/Vietnam/1204/2004 in complex with D04 Fab
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ume
Q-score: 0.462
Feldman J, Ramos ASF, Vu M, Maurer DP, Rosado VC, Lingwood D, Bajic G, Schmidt AG
Sci Immunol (2025) 10 pp. eado9572-eado9572 [ Pubmed: 39854479 DOI: doi:10.1126/sciimmunol.ado9572 ]
- Fab light chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab heavy chain (24 kDa, Protein from Homo sapiens)
- Hemagglutinin (62 kDa, Protein from Influenza A virus)
- Ha/fab (350 MDa, Complex from Homo sapiens)
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 9ekf
Q-score: 0.597
Morano NC, Guo Y, Becker JE, Li Z, Yu J, Ho DD, Shapiro L, Kwong PD
Structure (2025) 33 pp. 228-233.e3 [ Pubmed: 39884273 DOI: doi:10.1016/j.str.2025.01.001 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 65c6 light chain (23 kDa, Protein from Homo sapiens)
- Complex of hemagglutinin from h5n1 ha a/texas/37/2024 with antibody (360 kDa, Complex from Homo sapiens)
- Fab 65c6 heavy chain (25 kDa, Protein from Homo sapiens)
- Hemagglutinin (65 kDa, Protein from Influenza A virus)
Cryo-EM structure of hemagglutinin H5 A/Texas/37/2024 in complex with LSTa and antibody CR9114
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9dwe
Q-score: 0.559
Good MR, Fernandez-Quintero ML, Ji W, Rodriguez AJ, Han J, Ward AB, Guthmiller JJ
Nat Commun (2024) 15 pp. 10768-10768 [ DOI: doi:10.1038/s41467-024-54934-3 Pubmed: 39737954 ]
- Hemagglutinin (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hemagglutinin h5 a/texas/37/2024 homotrimer bound to lsta and cr9114 fab (Complex from Homo sapiens)
- Cr9114 fab fab heavy chain (12 kDa, Protein from Homo sapiens)
- Hemagglutinin (65 kDa, Protein from Influenza A virus)
- Cr9114 fab (Complex from Homo sapiens)
- Cr9114 fab light chain (11 kDa, Protein from Homo sapiens)
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 9dzq
Q-score: 0.335
Miller RJ, Durie IA, Gingerich AD, Elbehairy MA, Branch AG, Davis RG, Abbadi N, Brindley MA, Mousa JJ
Nat Commun (2024) 15 pp. 10825-10825 [ DOI: doi:10.1038/s41467-024-55101-4 Pubmed: 39738006 ]
- Human antibody piv3hn-05 light chain (22 kDa, Protein from Homo sapiens)
- Human antibody piv3hn-13 heavy chain (23 kDa, Protein from Homo sapiens)
- Complex of the piv3 hn protein with two human antibodies (200 kDa, Complex from Human respirovirus 3)
- Hemagglutinin-neuraminidase (51 kDa, Protein from Human respirovirus 3)
- Human antibody piv3hn-13 light chain (23 kDa, Protein from Homo sapiens)
- Human antibody piv3hn-05 heavy chain (24 kDa, Protein from Homo sapiens)
Structure of UT14 Fab in complex with the head domain of H3 (A/Singapore/INFIMH-16-0019/2016)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8uzc
Q-score: 0.426
Park J, Bartzoka F, Georgiou G
To Be Published
- Structure of ut14 fab in complex with the head domain of h3 (a/singapore/infimh-16-0019/2016) (113 kDa, Complex)
- Ut14 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ut14 fab light chain (23 kDa, Protein from Homo sapiens)
- Hemagglutinin (65 kDa, Protein from Influenza A virus)
Vaccine elicited Fab C968.180 with influenza H10 JD13 HA trimer
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 9bu6
Q-score: 0.489
Mantus GE, Chopde AJ, Gorman J, Cominsky LY, Ourahmane A, Creanga A, Shimberg GD, Gillespie RA, Van Wazer DJ, Zhou T, Gajjala SR, Williams C, Maestle E, Reed DS, Serebryannyy L, Costner P, Holman L, Casazza JP, Koup RA, Dropulic LK, Kwong PD, McDermott AB, Kanekiyo M, Andrews SF
Sci Transl Med (2025) 17 pp. eadr8373-eadr8373 [ DOI: doi:10.1126/scitranslmed.adr8373 Pubmed: 39742506 ]
- Fab c968.180 heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hemagglutinin ha2 (26 kDa, Protein from Influenza A virus)
- Fab c968.180 light chain (11 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 (35 kDa, Protein from Influenza A virus)
- Vaccine elicited fab c968.180 with influenza h10 jd13 ha trimer (Complex from Influenza A virus)
Vaccine elicited Fab c115.131 with influenza H10 JD13 HA trimer
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 9bu8
Q-score: 0.414
Mantus GE, Chopde AJ, Gorman J, Cominsky LY, Ourahmane A, Creanga A, Shimberg GD, Gillespie RA, Van Wazer DJ, Zhou T, Gajjala SR, Williams C, Maestle E, Reed DS, Serebryannyy L, Costner P, Holman L, Casazza JP, Koup RA, Dropulic LK, Kwong PD, McDermott AB, Kanekiyo M, Andrews SF
Sci Transl Med (2025) 17 pp. eadr8373-eadr8373 [ DOI: doi:10.1126/scitranslmed.adr8373 Pubmed: 39742506 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hemagglutinin ha2 (26 kDa, Protein from Influenza A virus)
- Fab c115.131 light chain (11 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 (35 kDa, Protein from Influenza A virus)
- Vaccine elicited fab c115.131 with influenza h10 jd13 ha trimer (Complex from Influenza A virus)
- Fab c115.131 heavy chain (13 kDa, Protein from Homo sapiens)
Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85666
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9bdf
Q-score: 0.563
Maurer D, Ferreira Ramos AS, Bajic G, Aaron GS
To Be Published
- Adi-85666 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Adi-85666 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Ha/fab (350 MDa, Complex from Homo sapiens)
- Hemagglutinin (57 kDa, Protein from Influenza A virus)
Influenza A virus Hemagglutinin H3/Darwin/6/2021 in complex with Fab ADI-85647
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 9bdg
Q-score: 0.551
Maurer D, Ferreira Ramos AS, Bajic G, Aaron GS
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Influenza a virus hemagglutinin h3/darwin/6/2021 in complex with fab adi-85647 (350 kDa, Complex from Homo sapiens)
- Fab adi-85647 heavy chain (25 kDa, Protein from Homo sapiens)
- Ig-like domain-containing protein (23 kDa, Protein from Homo sapiens)
- Hemagglutinin (57 kDa, Protein from Influenza A virus)