Rat TRPV2 E724A/D725A bound to probenecid and 2-APB
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9b3z
Q-score: 0.519
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell VY
To Be Published
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8rcr
Q-score: 0.329
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8rcu
Q-score: 0.325
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 4-chloranyl-2-[2-(3-iodanylphenoxy)ethanoylamino]benzoic acid (431 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8rd9
Q-score: 0.2
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Cholesterol (386 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (84 kDa, Protein from Homo sapiens)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid (355 Da, Ligand)
GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vj6
Q-score: 0.323
Hale WD, Montano Romero A, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC
Nat Struct Mol Biol (2024) 31 pp. 1669-1679 [ Pubmed: 38834914 DOI: doi:10.1038/s41594-024-01328-0 ]
GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2
Resolution: 4.85 Å
EM Method: Single-particle
Fitted PDBs: 8vj7
Q-score: 0.218
Hale WD, Montano Romero A, Gonzalez CU, Jayaraman V, Lau AY, Huganir RL, Twomey EC
Nat Struct Mol Biol (2024) 31 pp. 1669-1679 [ Pubmed: 38834914 DOI: doi:10.1038/s41594-024-01328-0 ]
- Isoform flip of glutamate receptor 2 (89 kDa, Protein from Rattus norvegicus)
- Ampa receptor glua2 homotetramer (Complex from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- 4-[(5s,8r)-8-methyl-6,7,8,9-tetrahydro-2h,5h-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline (293 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8qxj
Q-score: 0.574
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 2'-deoxy-5'-o-[(r)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine (490 Da, Ligand)
- Water (18 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State I - Tense
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8qxk
Q-score: 0.62
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8qxl
Q-score: 0.541
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Triphosphate (257 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- 2'-deoxycytidine (227 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)