Rat TRPV2 WT bound to probenecid
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- Homotetramer of rat trpv2 wt (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
Rat TRPV2 WT in the presence of probenecid and 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
Rat TRPV2 E724A/D725A bound to 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
Rat TRPV2 E724A/D725A bound to probenecid
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
Rat TRPV2 E724A/D725A bound to probenecid and 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
PL-bound rat TRPV2 in nanodiscs
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 6wkn
Q-score: 0.49
Conde J, Pumroy RA, Baker C, Rodrigues T, Guerreiro A, Sousa BB, Marques MC, de Almeida BP, Lee S, Leites EP, Picard D, Samanta A, Vaz SH, Sieglitz F, Langini M, Remke M, Roque R, Weiss T, Weller M, Liu Y, Han S, Corzana F, Morais VA, Faria CC, Carvalho T, Filippakopoulos P, Snijder B, Barbosa-Morais NL, Moiseenkova-Bell VY, Bernardes GJL
ACS Cent Sci (2021) 7 pp. 868-881 [ Pubmed: 34079902 DOI: doi:10.1021/acscentsci.1c00070 ]
Apo full-length rat TRPV2 in nanodiscs, state 1
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6u84
Q-score: 0.485
Apo full-length rat TRPV2 in nanodiscs, state 2
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6u86
Q-score: 0.435
CBD-bound full-length rat TRPV2 in nanodiscs, state 2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6u88
Q-score: 0.527
Pumroy RA, Samanta A, Liu Y, Hughes TE, Zhao S, Yudin Y, Rohacs T, Han S, Moiseenkova-Bell VY
eLife (2019) 8 [ Pubmed: 31566564 DOI: doi:10.7554/eLife.48792 ]
- Homotetramer of rat trpv2 (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- Cannabidiol (314 Da, Ligand)