Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8rcr
Q-score: 0.329
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Cholesterol (386 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8rcu
Q-score: 0.325
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- 4-chloranyl-2-[2-(3-iodanylphenoxy)ethanoylamino]benzoic acid (431 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (83 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8rd9
Q-score: 0.2
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Cholesterol (386 Da, Ligand)
- Homotetramer (500 MDa, Complex from Homo sapiens)
- Transient receptor potential cation channel subfamily m member 4 (84 kDa, Protein from Homo sapiens)
- 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid (355 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8qxj
Q-score: 0.574
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 2'-deoxy-5'-o-[(r)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine (490 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State I - Tense
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8qxk
Q-score: 0.62
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8qxl
Q-score: 0.541
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Triphosphate (257 Da, Ligand)
- 2'-deoxycytidine (227 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8qxm
Q-score: 0.573
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8qxn
Q-score: 0.459
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8qxo
Q-score: 0.417
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Magnesium ion (24 Da, Ligand)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8quc
Q-score: 0.551
Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M
Nat Commun (2024) 15 pp. 2533-2533 [ DOI: doi:10.1038/s41467-024-46813-8 Pubmed: 38514618 ]
- Potassium voltage-gated channel subfamily c member 1 (58 kDa, Protein from Homo sapiens)
- (5r)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione (341 Da, Ligand)
- Homotetramer of human kv3.1a with modulator aut1 (240 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)