Rat TRPV2 WT bound to probenecid
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9b3u
Q-score: 0.61
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell VY
To Be Published
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- Homotetramer of rat trpv2 wt (Complex from Rattus norvegicus)
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9b3w
Q-score: 0.622
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell VY
To Be Published
Rat TRPV2 E724A/D725A bound to probenecid
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9b3y
Q-score: 0.558
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell VY
To Be Published
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
mouse TRPM4 with ligand DDM/CHS
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Homotetramer (500 MDa, Complex from Homo sapiens)
Ekundayo B, Arullampalam P, Gerber CE, Hammerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D
Nat Commun (2025) 16 pp. 833-833 [ DOI: doi:10.1038/s41467-025-56131-2 Pubmed: 39828793 ]
- Homotetramer (500 MDa, Complex from Homo sapiens)
Structure of human pyruvate carboxylase
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8xl9
Q-score: 0.559
Zhou FY, Zhang YY, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/eLife.98885.2 ]
- Biotin (244 Da, Ligand)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from Homo sapiens)
- Homotetramer complex of human pyruvate carboxylase (Complex from Homo sapiens)
Myo-inositol-1-phosphate synthase from Thermochaetoides thermophila in complex with NAD
Trager TK, Kyrilis FL, Hamdi F, Tuting C, Alfes M, Hofmann T, Schmidt C, Kastritis PL
PNAS (2024) 121 pp. e2400912121-e2400912121 [ DOI: doi:10.1073/pnas.2400912121 Pubmed: 39145930 ]
Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8qxj
Q-score: 0.574
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 2'-deoxy-5'-o-[(r)-hydroxy{[(r)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine (490 Da, Ligand)
- Water (18 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State I - Tense
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8qxk
Q-score: 0.62
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8qxl
Q-score: 0.541
Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA
Nat Commun (2024) 15 pp. 3775-3775 [ DOI: doi:10.1038/s41467-024-48237-w Pubmed: 38710701 ]
- Deoxynucleoside triphosphate triphosphohydrolase samhd1 (72 kDa, Protein from Homo sapiens)
- Homotetramer of samhd1 (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Triphosphate (257 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- 2'-deoxycytidine (227 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)