cryo-EM structure of human mTOR complex 2, overall refinement
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6zwm
Q-score: 0.396
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- Rapamycin-insensitive companion of mtor (192 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Acetyl group (44 Da, Ligand)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Target of rapamycin complex 2 subunit mapkap1 (59 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
cryo-EM structure of human mTOR complex 2 in absence of ATP-gamma-S
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Target of rapamycin complex 2 subunit mapkap1 (Protein from Homo sapiens)
- Rapamycin-insensitive companion of mtor (Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
Human mTOR complex 2 with additional density close to the mLST8
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Target of rapamycin complex 2 subunit mapkap1 (Protein from Homo sapiens)
- Rapamycin-insensitive companion of mtor (Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
Human mTOR complex 2 with additional density close to the mLST8
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Target of rapamycin complex 2 subunit mapkap1 (Protein from Homo sapiens)
- Rapamycin-insensitive companion of mtor (Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
cryo-EM structure of human mTOR complex 2, focused on one half
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6zwo
Q-score: 0.527
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- Rapamycin-insensitive companion of mtor (192 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Acetyl group (44 Da, Ligand)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Target of rapamycin complex 2 subunit mapkap1 (59 kDa, Protein from Homo sapiens)
4.9 Angstrom Cryo-EM structure of human mTOR complex 2
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 5zcs
Q-score: 0.164
Chen X, Liu M, Tian Y, Li J, Qi Y, Zhao D, Wu Z, Huang M, Wong CCL, Wang HW, Wang J, Yang H, Xu Y
Cell Res (2018) 28 pp. 518-528 [ DOI: doi:10.1038/s41422-018-0029-3 Pubmed: 29567957 ]
- Target of rapamycin complex 2 subunit mapkap1 (55 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- Rapamycin-insensitive companion of mtor (175 kDa, Protein from Homo sapiens)
- Human mtor complex 2 (1 GDa, Complex from Homo sapiens)