cryo-EM structure of human mTOR complex 2, overall refinement
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6zwm
Q-score: 0.396
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Zinc ion (65 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- Target of rapamycin complex 2 subunit mapkap1 (59 kDa, Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
- Rapamycin-insensitive companion of mtor (192 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Acetyl group (44 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
cryo-EM structure of human mTOR complex 2 in absence of ATP-gamma-S
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Target of rapamycin complex 2 subunit mapkap1 (Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
- Rapamycin-insensitive companion of mtor (Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (Protein from Homo sapiens)
Human mTOR complex 2 with additional density close to the mLST8
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Target of rapamycin complex 2 subunit mapkap1 (Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
- Rapamycin-insensitive companion of mtor (Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (Protein from Homo sapiens)
Human mTOR complex 2 with additional density close to the mLST8
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Target of rapamycin complex 2 subunit mapkap1 (Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
- Rapamycin-insensitive companion of mtor (Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (Protein from Homo sapiens)
cryo-EM structure of human mTOR complex 2, focused on one half
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6zwo
Q-score: 0.527
Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1251 Pubmed: 33158864 ]
- Zinc ion (65 Da, Ligand)
- Inositol hexakisphosphate (660 Da, Ligand)
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- Target of rapamycin complex 2 subunit mapkap1 (59 kDa, Protein from Homo sapiens)
- Human mtor complex 2 (1 MDa, Complex from Homo sapiens)
- Rapamycin-insensitive companion of mtor (192 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Acetyl group (44 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)