Structure of human soluble guanylate cyclase in the inactive state at 3.1 angstrom
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hbe
Q-score: 0.526
Nitric Oxide (2023) 134-135 pp. 17-22 [ DOI: doi:10.1016/j.niox.2023.03.002 Pubmed: 36972843 ]
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
Structure of human soluble guanylate cyclase in the NO+Rio state at 3.1 angstrom
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8hbf
Q-score: 0.539
Nitric Oxide (2023) 134-135 pp. 17-22 [ DOI: doi:10.1016/j.niox.2023.03.002 Pubmed: 36972843 ]
- Magnesium ion (24 Da, Ligand)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Methyl ~{n}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{n}-methyl-carbamate (422 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Nitric oxide (30 Da, Ligand)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human soluble guanylate cyclase in the NO-activated state at 3.1 angstrom
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8hbh
Q-score: 0.537
Nitric Oxide (2023) 134-135 pp. 17-22 [ DOI: doi:10.1016/j.niox.2023.03.002 Pubmed: 36972843 ]
- Magnesium ion (24 Da, Ligand)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Nitric oxide (30 Da, Ligand)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human SGLT2-MAP17 complex bound with empagliflozin
Niu Y, Liu R, Guan C, Zhang Y, Chen Z, Hoerer S, Nar H, Chen L
Nature (2022) 601 pp. 280-284 [ DOI: doi:10.1038/s41586-021-04212-9 Pubmed: 34880493 ]
- Palmitic acid (256 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- (2s,3r,4r,5s,6r)-2-[4-chloranyl-3-[[4-[(3s)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol (450 Da, Ligand)
- Pdzk1-interacting protein 1 (5 kDa, Protein from Homo sapiens)
- Sodium/glucose cotransporter 2 (72 kDa, Protein from Homo sapiens)
Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7d9r
Q-score: 0.458
Nat Commun (2021) 12 pp. 5492-5492 [ Pubmed: 34535643 DOI: doi:10.1038/s41467-021-25617-0 ]
- Magnesium ion (24 Da, Ligand)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Methyl ~{n}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{n}-methyl-carbamate (422 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7d9s
Q-score: 0.452
Nat Commun (2021) 12 pp. 5492-5492 [ Pubmed: 34535643 DOI: doi:10.1038/s41467-021-25617-0 ]
- Magnesium ion (24 Da, Ligand)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- [5-[1-(phenylmethyl)indazol-3-yl]furan-2-yl]methanol (304 Da, Ligand)
Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7d9t
Q-score: 0.417
Nat Commun (2021) 12 pp. 5492-5492 [ Pubmed: 34535643 DOI: doi:10.1038/s41467-021-25617-0 ]
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
- 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid (565 Da, Ligand)
Structure of human soluble guanylate cyclase in the cinciguat-bound activated state
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7d9u
Q-score: 0.445
Nat Commun (2021) 12 pp. 5492-5492 [ DOI: doi:10.1038/s41467-021-25617-0 Pubmed: 34535643 ]
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid (565 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
Structure of human soluble guanylate cyclase in the NO activated state
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6jt2
Q-score: 0.411
Nature (2019) 574 pp. 206-210 [ Pubmed: 31514202 DOI: doi:10.1038/s41586-019-1584-6 ]
- Magnesium ion (24 Da, Ligand)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human soluble guanylate cyclase in the unliganded state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6jt0
Q-score: 0.357
Nature (2019) 574 pp. 206-210 [ DOI: doi:10.1038/s41586-019-1584-6 Pubmed: 31514202 ]
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Human soluble guanylate cyclase (Complex from Homo sapiens)