Cryo-EM structure of DHEA-ADGRG2-FL-Gs complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xke
Q-score: 0.532
Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X
Nat Chem Biol (2022) 18 pp. 1196-1203 [ Pubmed: 35982227 DOI: doi:10.1038/s41589-022-01084-6 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- 3-beta-hydroxy-5-androsten-17-one (288 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (220 kDa, Complex from Mus musculus)
- Nb35 (13 kDa, Protein from Camelus bactrianus)
- Adhesion g-protein coupled receptor g2 (98 kDa, Protein from Mus musculus)
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7wui
Q-score: 0.418
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X
Nature (2022) 604 pp. 771-778 [ DOI: doi:10.1038/s41586-022-04590-8 Pubmed: 35418677 ]
- Nanobody-35 (Complex from Lama glama)
- Nanobody-35 (13 kDa, Protein from Lama glama)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Ip15 (1 kDa, Protein from synthetic construct)
- Ip15 (Complex)
- Cryo-em structure of the adgrg2-fl-ip15-gs complex (253 MDa, Complex)
- Adhesion g-protein coupled receptor g2,mcherry (126 kDa, Protein from Mus musculus)
- Scfv16 (Complex from synthetic construct)
- Gs (Complex from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (Complex from Mus musculus)
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wuj
Q-score: 0.474
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X
Nature (2022) 604 pp. 771-778 [ DOI: doi:10.1038/s41586-022-04590-8 Pubmed: 35418677 ]
- Nanobody-35 (Complex from Lama glama)
- Nanobody-35 (13 kDa, Protein from Lama glama)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g4,uncharacterized protein (71 kDa, Protein from Psychromonas sp. B3M02)
- Cryo-em structure of the adgr4-beta-gs complex (Complex)
- Scfv16 (Complex from synthetic construct)
- Gs (Complex from Homo sapiens)
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vab
Q-score: 0.437
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ DOI: doi:10.1038/s41467-022-28683-0 Pubmed: 35217653 ]
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with non-acylated_tirzepatide and g protein (Complex from Homo sapiens)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Non-acylated_tirzepatide (4 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Nonobody-35 (15 kDa, Protein from synthetic construct)