Cryo-EM structure of LPS-bound GPR174 in complex with Gs protein
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 7xv3
Q-score: 0.579
Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y
Nat Commun (2023) 14 pp. 1012-1012 [ DOI: doi:10.1038/s41467-023-36575-0 Pubmed: 36823105 ]
- Water (18 Da, Ligand)
- (2~{s})-2-$l^{4}-azanyl-3-[[(2~{r})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid (497 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered g protein subunit s (mini-gs) (41 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 174 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Lama glama)
- Gpr174/gs complex (Complex from Homo sapiens)
Structure of A2BR bound to synthetic agonists BAY 60-6583
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8hdo
Q-score: 0.497
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y
Cell Discov (2022) 8 pp. 140-140 [ Pubmed: 36575181 DOI: doi:10.1038/s41421-022-00503-1 ]
- A2br-g protein-bay 60-6583 complex (160 kDa, Complex from Homo sapiens)
- Adenosine a2b receptor (36 kDa, Protein from Homo sapiens)
- 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide (379 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Chimeric minigs (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody 35 (13 kDa, Protein from Camelus bactrianus)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of DHEA-ADGRG2-FL-Gs complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7xke
Q-score: 0.532
Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X
Nat Chem Biol (2022) 18 pp. 1196-1203 [ Pubmed: 35982227 DOI: doi:10.1038/s41589-022-01084-6 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- 3-beta-hydroxy-5-androsten-17-one (288 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (220 kDa, Complex from Mus musculus)
- Nb35 (13 kDa, Protein from Camelus bactrianus)
- Adhesion g-protein coupled receptor g2 (98 kDa, Protein from Mus musculus)
Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7t9i
Q-score: 0.375
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ DOI: doi:10.1038/s41586-022-05159-1 Pubmed: 35940205 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Thyrotropin subunit beta (12 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7t9n
Q-score: 0.495
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ DOI: doi:10.1038/s41586-022-05159-1 Pubmed: 35940205 ]
- (2s)-3-hydroxypropane-1,2-diyl dihexadecanoate (568 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- M22 fab heavy chain (27 kDa, Protein from Homo sapiens)
- M22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure) (Complex)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- M22 fab light chain (25 kDa, Protein from Homo sapiens)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7utz
Q-score: 0.52
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ DOI: doi:10.1038/s41586-022-05159-1 Pubmed: 35940205 ]
- (2s)-3-hydroxypropane-1,2-diyl dihexadecanoate (568 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Human tsh analog tr1402 bound to human thyrotropin receptor in complex with minigs399 (composite structure) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Glycoprotein hormones alpha chain analog tr1402 (10 kDa, Protein from Homo sapiens)
- Thyrotropin subunit beta (12 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the adhesion GPCR ADGRD1 in complex with miniGs
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7wu2
Q-score: 0.53
Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B
Nature (2022) 604 pp. 779-785 [ DOI: doi:10.1038/s41586-022-04580-w Pubmed: 35418679 ]
- Nanobody nb35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor d1 (38 kDa, Protein from Homo sapiens)
- Nanobody nb35 (Complex from Lama glama)
- The adhesion gpcr adgrd1 in complex with minigs (Complex from Homo sapiens)
Human Neurokinin 1 receptor (NK1R) substance P Gs complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7p02
Q-score: 0.502
Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A
Sci Adv (2021) 7 pp. eabk2872-eabk2872 [ Pubmed: 34878828 DOI: doi:10.1126/sciadv.abk2872 ]
- Nk1r in complex with substance p, heterotrimeric mini-gs chimera (gsi) and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Substance-p receptor (44 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (32 kDa, Protein from Mus musculus)
- Protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)