Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7f4d
Q-score: 0.478
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE
Cell Res (2021) 31 pp. 1061-1071 [ DOI: doi:10.1038/s41422-021-00557-y Pubmed: 34453129 ]
- Cryo-em structure of alpha-msh-bound melanocortin-1 receptor in complex with gs protein and nb35 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Alpha-melanocyte-stimulating hormone (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from synthetic construct)
- Melanocortin-1 receptor (68 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Melanocortin-1 receptor (Complex)
- Alpha-melanocyte-stimulating hormone (Complex)
- Nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7f4h
Q-score: 0.52
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE
Cell Res (2021) 31 pp. 1061-1071 [ DOI: doi:10.1038/s41422-021-00557-y Pubmed: 34453129 ]
- Cryo-em structure of afamelanotide-bound melanocortin-1 receptor in complex with gs protein, nb35 and scfv16 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from synthetic construct)
- Scfv16 (Complex)
- Afamelanotide (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Melanocortin-1 receptor (68 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Afamelanotide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Melanocortin-1 receptor (Complex from synthetic construct)
Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7f4i
Q-score: 0.474
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE
Cell Res (2021) 31 pp. 1061-1071 [ DOI: doi:10.1038/s41422-021-00557-y Pubmed: 34453129 ]
- Calcium ion (40 Da, Ligand)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Shu9119 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Melanocortin-1 receptor (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Melanocortin-1 receptor (68 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Homo sapiens)
- Shu9119 (Complex)
- Cryo-em structure of shu9119-bound melanocortin-1 receptor in complex with gs protein and nb35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7dty
Q-score: 0.436
Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW
eLife (2021) 10 [ DOI: doi:10.7554/eLife.68719 Pubmed: 34254582 ]
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with gip and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide (4 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Human glucose-dependent insulinotropic polypeptide receptor (64 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)