Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8itl
Q-score: 0.477
Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW
PNAS (2023) 120 pp. e2306145120-e2306145120 [ Pubmed: 37792509 DOI: doi:10.1073/pnas.2306145120 ]
- Gastric inhibitory polypeptide receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of a splice variant of the gipr(sv1) in complex with gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8itm
Q-score: 0.479
Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW
PNAS (2023) 120 pp. e2306145120-e2306145120 [ Pubmed: 37792509 DOI: doi:10.1073/pnas.2306145120 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Gastric inhibitory polypeptide receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of a splice variant of the gipr(sv2) in complex with gs protein (Complex from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8ioc
Q-score: 0.459
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ Pubmed: 37524700 DOI: doi:10.1107/S0907444909042073 ]
- Gamma-melanocyte-stimulating hormone (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Ha signal peptide,melanocortin receptor 3,lgbit subunit (56 kDa, Protein from Homo sapiens)
- Cryo-em structure of gamma-msh-bound human melanocortin receptor 3 in complex with g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Nanobody-35 (17 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8iod
Q-score: 0.503
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ Pubmed: 37524700 DOI: doi:10.1107/S0907444909042073 ]
- Pg-901 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of pg-901-bound human melanocortin receptor 5 in complex with g protein (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Ha signal peptide,melanocortin receptor 5,lgbit subunit (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (17 kDa, Protein from Homo sapiens)
Cryo-EM structure of a class A orphan GPCR
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7y3g
Q-score: 0.486
Li H, Zhang J, Yu Y, Luo F, Wu L, Liu J, Chen N, Liu Z, Hua T
Sci Bull (Beijing) (2023) 68 pp. 95-104 [ DOI: doi:10.1016/j.scib.2022.12.023 Pubmed: 36593162 ]
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 12 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Complex of gpcr and g protein (150 kDa, Complex from Homo sapiens)
- Nanobody 35 (Complex from Homo sapiens)
- G-protein coupled receptor 12 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Lama glama)
Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xt8
Q-score: 0.533
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE
Mol Cell (2022) 82 pp. 2681-2695.e6 [ DOI: doi:10.1016/j.molcel.2022.05.031 Pubmed: 35714614 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Serotonin 4 (5-ht4) receptor-gs-nb35 complex (Complex from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 4 (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Serotonin (176 Da, Ligand)
Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7xtb
Q-score: 0.46
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE
Mol Cell (2022) 82 pp. 2681-2695.e6 [ DOI: doi:10.1016/j.molcel.2022.05.031 Pubmed: 35714614 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 6 (63 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Serotonin 6 (5-ht6) receptor-gs-nb35 complex (Complex from Homo sapiens)
Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xtc
Q-score: 0.455
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE
Mol Cell (2022) 82 pp. 2681-2695.e6 [ Pubmed: 35714614 DOI: doi:10.1016/j.molcel.2022.05.031 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 7 (64 kDa, Protein from Homo sapiens)
- 3-(2-azanylethyl)-1h-indole-5-carboxamide (203 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Serotonin 7 (5-ht7) receptor-gs-nb35 complex (Complex from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
Human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7vqx
Q-score: 0.543
Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW
Nat Commun (2022) 13 pp. 2272-2272 [ DOI: doi:10.1038/s41467-022-30041-z Pubmed: 35477937 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Vasoactive intestinal polypeptide receptor 2 (64 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Pituitary adenylate cyclase-activating polypeptide 27 (3 kDa, Protein from Homo sapiens)
- Nanobody-35 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex)
- Human vasoactive intestinal polypeptide receptor 2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) /g(s) /g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the human vasoactive intestinal polypeptide receptor 2 in commplex with pacap27 and g protein (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i) /g(s) /g(t) subunit beta-1 (Complex from synthetic construct)
- Pituitary adenylate cyclase activating peptide-27 (Complex from Bos taurus)
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7wbj
Q-score: 0.425
Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW
Nat Commun (2022) 13 pp. 2272-2272 [ DOI: doi:10.1038/s41467-022-30041-z Pubmed: 35477937 ]
- Vasoactive intestinal polypeptide receptor 2 (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from synthetic construct)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Pituitary adenylate cyclase-activating polypeptide 27 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the human vasoactive intestinal polypeptide receptor 2 in commplex with pacap27 and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Vasoactive intestinal polypeptide receptor 2 (Complex)
- Pituitary adenylate cyclase-activating polypeptide 27 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short/g(i)/g(s)/g(o) subunit gamma-2 (Complex from Rattus norvegicus)
- Nanobody-35 (Complex)