Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex.
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7ckw
Q-score: 0.431
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
- Em stucture of complex-1 (Complex from Homo sapiens)
- Protein-1 (Complex)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7ckx
Q-score: 0.389
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Em structure of protein-2 (Complex)
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (1r,3s)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1h-isochromene-5,6-diol (329 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7cky
Q-score: 0.254
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Complex structure-3 (Complex)
- 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione (389 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ckz
Q-score: 0.451
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Complex structure-4 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- 2-[2,6-bis(chloranyl)phenyl]-1-[(1s,3r)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone (450 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- L-dopamine (153 Da, Ligand)
Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7crh
Q-score: 0.419
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein alpha, beta-1 and gamma-2 (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody35 (16 kDa, Protein from Lama glama)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- (1s)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol (317 Da, Ligand)
- Em structure of receptor signaling complex-5 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)