Consensus olfactory receptor consOR51 in complex with mini-Gs trimeric protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8uxv
Q-score: 0.544
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Consor51 (36 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Minigs399 (30 kDa, Protein from Homo sapiens)
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
Consensus olfactory receptor consOR1 bound to L-menthol and in complex with mini-Gs trimeric protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8uxy
Q-score: 0.402
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- (1r,2s,5r)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol (156 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Consor1 (35 kDa, Protein from synthetic construct)
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
Consensus olfactory receptor consOR2 bound to S-carvone and in complex with mini-Gs trimeric protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8uy0
Q-score: 0.489
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Consor2 (35 kDa, Protein from synthetic construct)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (5s)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one (150 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Consor2-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Minigs399 (30 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8uyq
Q-score: 0.262
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ Pubmed: 39478229 DOI: doi:10.1038/s41586-024-08126-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Consor4 (36 kDa, Protein from synthetic construct)
- (2r)-2-methyl-1,3-thiazolidine (103 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Consor4-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8f76
Q-score: 0.52
Billesbolle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A
Nature (2023) 615 pp. 742-749 [ Pubmed: 36922591 DOI: doi:10.1038/s41586-023-05798-y ]
- Propanoic acid (74 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Olfactory receptor 51e2 (36 kDa, Protein from Homo sapiens)
- Or51e2-gs complex (100 kDa, Complex from Homo sapiens)