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sample_name:"nanobody 35" AND author_orcid:"0000-0003-2861-3397"
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982
Release date: Oct. 30, 2024
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8vhf
Q-score: 0.449
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8vhf
Q-score: 0.449
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
Sample:
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, hibit (40 kDa, Protein from Homo sapiens)
- The complex of gpr119-gs-nb35 (composite map) (177 kDa, Complex)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (67 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- G-protein complex (93 kDa, Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982 (consensus map)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
Sample:
- Nanobody35 (Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Gpr119-gs-nb35 complex (177 kDa, Complex)
- G-protein complex (Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
Sample:
- Nanobody35 (Protein from Lama glama)
- Gpr119-gs-nb35 complex (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- G-protein complex (Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
Sample:
- Gs-nb35 complex (110 kDa, Complex)
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
- G-protein complex (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Nanobody35 (Protein from Lama glama)
- Gpr119-gs-nb35 complex (Complex)
- Guanine nucleotide-bindign protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
Sample:
- Heterotrimeric gs protein (Complex from Homo sapiens)
- Nanobody35 (Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Oea-gpr119-gs-nb35 complex (177 kDa, Complex)
- Glucose-dependent insulinotropic receptor gpr119 (Complex from Escherichia coli)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor gpr119,lgbit (Protein from synthetic construct)