Cryo-EM structure of the GLP-1R/GCGR dual agonist peptide15-bound human GLP-1R-Gs complex
Resolution: 2.46 Å
EM Method: Single-particle
Fitted PDBs: 8jis
Q-score: 0.499
Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z
PNAS (2023) 120 pp. e2303696120-e2303696120 [ DOI: doi:10.1073/pnas.2303696120 Pubmed: 37549266 ]
- Peptide 15 (3 kDa, Protein from synthetic construct)
- Cryo-em structure of the glp-1r/gcgr dual agonist peptide 15-bound human glp-1r-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Bos taurus)
- Nanobody 35 (13 kDa, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8itl
Q-score: 0.477
Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW
PNAS (2023) 120 pp. e2306145120-e2306145120 [ DOI: doi:10.1073/pnas.2306145120 Pubmed: 37792509 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of a splice variant of the gipr(sv1) in complex with gs protein (Complex from Homo sapiens)
- Gastric inhibitory polypeptide receptor (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8itm
Q-score: 0.479
Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW
PNAS (2023) 120 pp. e2306145120-e2306145120 [ DOI: doi:10.1073/pnas.2306145120 Pubmed: 37792509 ]
- Cryo-em structure of a splice variant of the gipr(sv2) in complex with gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide receptor (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GLP-1R/GCGR dual agonist Peptide 15-bound human GCGR-Gs complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jiq
Q-score: 0.437
Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z
PNAS (2023) 120 pp. e2303696120-e2303696120 [ Pubmed: 37549266 DOI: doi:10.1073/pnas.2303696120 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Peptide 15 (3 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucagon receptor (46 kDa, Protein from Homo sapiens)
- Cryo-em structure of the glp-1r/gcgr dual agonist peptide 15-bound human gcgr-gs complex (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GCGR-Gs complex
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8jiu
Q-score: 0.46
Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z
PNAS (2023) 120 pp. e2303696120-e2303696120 [ Pubmed: 37549266 DOI: doi:10.1073/pnas.2303696120 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucagon receptor (46 kDa, Protein from Homo sapiens)
- Cryo-em structure of the glp-1r/gcgr dual agonist sar425899-bound human gcgr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Nanobody 35 (15 kDa, Protein from Escherichia coli)
- Sar425899 (3 kDa, Protein from synthetic construct)
Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GLP-1R-Gs complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8jip
Q-score: 0.439
Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z
PNAS (2023) 120 pp. e2303696120-e2303696120 [ Pubmed: 37549266 DOI: doi:10.1073/pnas.2303696120 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Medi0382 (3 kDa, Protein from synthetic construct)
- Cryo-em structure of the glp-1r/gcgr dual agonist medi0382-bound human glp-1r-gs complex (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GLP-1R-Gs complex
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8jir
Q-score: 0.51
Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z
PNAS (2023) 120 pp. e2303696120-e2303696120 [ Pubmed: 37549266 DOI: doi:10.1073/pnas.2303696120 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the glp-1r/gcgr dual agonist sar425899-bound human glp-1r-gs complex (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Escherichia coli)
- Sar425899 (3 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GLP-1R/GCGR dual agonist MEDI0382-bound human GCGR-Gs complex
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8jit
Q-score: 0.472
Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z
PNAS (2023) 120 pp. e2303696120-e2303696120 [ Pubmed: 37549266 DOI: doi:10.1073/pnas.2303696120 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Medi0382 (3 kDa, Protein from synthetic construct)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucagon receptor (46 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the glp-1r/gcgr dual agonist medi0382-bound human gcgr-gs complex (Complex from Homo sapiens)
Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 7x8r
Q-score: 0.554
Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW
PNAS (2022) 119 pp. e2200155119-e2200155119 [ DOI: doi:10.1073/pnas.2200155119 Pubmed: 35561211 ]
- 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid (1 kDa, Ligand)
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with boc5 and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7x8s
Q-score: 0.482
Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW
PNAS (2022) 119 pp. e2200155119-e2200155119 [ DOI: doi:10.1073/pnas.2200155119 Pubmed: 35561211 ]
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with wb4-24 and g protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-(2-methylpropanoylamino)phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid (1 kDa, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)