Cryo-EM structure of a class T GPCR in active state
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 7xp6
Q-score: 0.415
Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T
Science (2022) 377 pp. 1298-1304 [ DOI: doi:10.1126/science.abo1633 Pubmed: 36108005 ]
- Strychnine (334 Da, Ligand)
- Complex of gpcr and g protein (Complex from Homo sapiens)
- Endoglucanase h,taste receptor type 2 member 46,endoglucanase h,taste receptor type 2 member 46,bitter taste receptor t2r46 (91 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (30 kDa, Protein from Homo sapiens)
Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7tyi
Q-score: 0.463
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Palmitic acid (256 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Calcitonin receptor in complex with gs and rat amylin peptide, ct-like state (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Islet amyloid polypeptide (3 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Calcitonin Receptor in complex with Gs and salmon calcitonin peptide
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7tyn
Q-score: 0.575
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Palmitic acid (256 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Calcitonin-1 (3 kDa, Protein from Salmo salar)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcitonin receptor in complex with gs and salmon calcitonin peptide (Complex)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Human Amylin2 Receptor in complex with Gs and rat amylin peptide
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 7tyx
Q-score: 0.488
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Human amylin2 receptor in complex with gs and rat amylin peptide (Complex)
- Palmitic acid (256 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Receptor activity-modifying protein 2 (17 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Amylin peptide (3 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human Amylin1 Receptor in complex with Gs and rat amylin peptide
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7tyf
Q-score: 0.631
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Human amylin1 receptor in complex with gs and rat amylin peptide (Complex)
- Water (18 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Amylin peptide (3 kDa, Protein from Rattus norvegicus)
- Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7tyw
Q-score: 0.477
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Calcitonin-1 (3 kDa, Protein from Salmo salar)
- Human amylin 1 receptor in complex with gs and salmon calcitonin peptide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7tyy
Q-score: 0.509
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Human amylin 2 receptor in complex with gs and salmon calcitonin peptide (Complex)
- Water (18 Da, Ligand)
- Calcitonin-1 (3 kDa, Protein from Salmo salar)
- Receptor activity-modifying protein 2 (17 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human Amylin3 Receptor in complex with Gs and rat amylin peptide
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7tzf
Q-score: 0.564
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Receptor activity-modifying protein 3 (16 kDa, Protein from Homo sapiens)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Amylin peptide (3 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human amylin 3 receptor in complex with gs and rat amylin peptide (Complex)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6nbf
Q-score: 0.444
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y
Science (2019) 364 pp. 148-153 [ Pubmed: 30975883 DOI: doi:10.1126/science.aav7942 ]
- Palmitic acid (256 Da, Ligand)
- Cryo-em structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and g protein (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Long-acting parathyroid hormone analog (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gs protein alpha subunit (43 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6nbh
Q-score: 0.347
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y
Science (2019) 364 pp. 148-153 [ Pubmed: 30975883 DOI: doi:10.1126/science.aav7942 ]
- Palmitic acid (256 Da, Ligand)
- Cryo-em structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and g protein (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Long-acting parathyroid hormone analog (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gs protein alpha subunit (43 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)