Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7rmg
Q-score: 0.532
Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A
Nat Chem Biol (2022) 18 pp. 109-115 [ DOI: doi:10.1038/s41589-021-00890-8 Pubmed: 34711980 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1/gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Substance-p receptor (47 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, with certain residues mutated to match guanine nucleotide-binding protein g(q) subunit (26 kDa, Protein from Homo sapiens)
- Substance p (1 kDa, Protein from Homo sapiens)
- Substance-p receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s)/g(q) subunit alpha hybrid (Complex from Homo sapiens)
- Substance p bound to neurokinin 1 receptor-minigs/q70 complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Substance p (Complex from Homo sapiens)
Substance P bound to active human neurokinin 1 receptor in complex with miniGs399
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7rmh
Q-score: 0.492
Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A
Nat Chem Biol (2022) 18 pp. 109-115 [ Pubmed: 34711980 DOI: doi:10.1038/s41589-021-00890-8 ]
- Minigs399 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Substance-p receptor (Complex from Homo sapiens)
- Substance p (1 kDa, Protein from Homo sapiens)
- Substance p (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1/gamma-2 (Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Nanobody 35 (Complex from Lama glama)
- Substance-p receptor (47 kDa, Protein from Homo sapiens)
- Substance p bound to neurokinin1 receptor-minigs399 complex (Complex)
SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7rmi
Q-score: 0.458
Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A
Nat Chem Biol (2022) 18 pp. 109-115 [ DOI: doi:10.1038/s41589-021-00890-8 Pubmed: 34711980 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1/gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Substance-p receptor (47 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, with certain residues mutated to match guanine nucleotide-binding protein g(q) subunit (26 kDa, Protein from Homo sapiens)
- Substance-p receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s)/g(q) subunit alpha hybrid (Complex from Homo sapiens)
- Substance p bound to neurokinin 1 receptor-minigs/q70 complex (Complex)
- Substance p 6-11 (739 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Substance p 6-11 (Complex from synthetic construct)