Human PTH1R in complex with PTH(1-34) and Gs
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8flq
Q-score: 0.538
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ Pubmed: 37148874 DOI: doi:10.1016/j.str.2023.04.002 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pth bound to the pth1r in complex with g protein (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
Human PTH1R in complex with PTHrP and Gs
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8flr
Q-score: 0.516
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ Pubmed: 37148874 DOI: doi:10.1016/j.str.2023.04.002 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Pthrp[1-36] (4 kDa, Protein from Homo sapiens)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Pthrp bound to the pth1r in complex with g protein (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Human PTH1R in complex with LA-PTH and Gs
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8flu
Q-score: 0.463
Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM
Structure (2023) 31 pp. 668-676.e5 [ Pubmed: 37148874 DOI: doi:10.1016/j.str.2023.04.002 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Long-acting pth (4 kDa, Protein from synthetic construct)
- Human pth1r in complex with la-pth and gs (Complex from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (69 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
Structure of A2BR bound to synthetic agonists BAY 60-6583
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8hdo
Q-score: 0.497
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y
Cell Discov (2022) 8 pp. 140-140 [ Pubmed: 36575181 DOI: doi:10.1038/s41421-022-00503-1 ]
- Nanobody 35 (13 kDa, Protein from Camelus bactrianus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- A2br-g protein-bay 60-6583 complex (160 kDa, Complex from Homo sapiens)
- Adenosine a2b receptor (36 kDa, Protein from Homo sapiens)
- 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide (379 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Chimeric minigs (29 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Structure of A2BR bound to endogenous agonists adenosine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hdp
Q-score: 0.428
Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y
Cell Discov (2022) 8 pp. 140-140 [ Pubmed: 36575181 DOI: doi:10.1038/s41421-022-00503-1 ]
- Nanobody 35 (13 kDa, Protein from Camelus bactrianus)
- A2br-g protein-adenosine complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Adenosine a2b receptor (36 kDa, Protein from Homo sapiens)
- Adenosine (267 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Chimeric minigs (29 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 7xw5
Q-score: 0.482
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- Glycoprotein hormones alpha chain (10 kDa, Protein from Homo sapiens)
- Thyrotropin subunit beta (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Nanobody35 (14 kDa, Protein from Lama glama)
- Tshr-thyroid stimulating hormone-gs-ml109 complex (Complex from Homo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7xz6
Q-score: 0.552
Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE
Nat Struct Mol Biol (2022) 29 pp. 863-870 [ DOI: doi:10.1038/s41594-022-00816-5 Pubmed: 35970999 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate (477 Da, Ligand)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Nb35 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Gpr119-gs (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr119-gs-nb35-apd668 complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor (53 kDa, Protein from Homo sapiens)
TSHR-Gs-M22 antibody-ML109 complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 7xw6
Q-score: 0.441
Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE
Nature (2022) 609 pp. 854-859 [ Pubmed: 35940204 DOI: doi:10.1038/s41586-022-05173-3 ]
- The complex was assembled by co-expression. (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody35 (14 kDa, Protein from Homo sapiens)
- M22 antibody light chain (11 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- ~{n}-[4-[[2-methoxy-5-[(2~{s})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide (523 Da, Ligand)
- M22 antibody heavy chain (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Serotonin 4 (5-HT4) receptor-Gs-Nb35 complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xt8
Q-score: 0.533
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE
Mol Cell (2022) 82 pp. 2681-2695.e6 [ Pubmed: 35714614 DOI: doi:10.1016/j.molcel.2022.05.031 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Serotonin 4 (5-ht4) receptor-gs-nb35 complex (Complex from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 4 (59 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7xtb
Q-score: 0.46
Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE
Mol Cell (2022) 82 pp. 2681-2695.e6 [ Pubmed: 35714614 DOI: doi:10.1016/j.molcel.2022.05.031 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Serotonin 6 (5-ht6) receptor-gs-nb35 complex (Complex from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 6 (63 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)