Cryo-EM structure of the fenoldopam-bound D1 dopamine receptor and mini-Gs complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7x2c
Q-score: 0.465
Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S
Nat Commun (2022) 13 pp. 3186-3186 [ DOI: doi:10.1038/s41467-022-30929-w Pubmed: 35676276 ]
- Nanobody35 (Complex)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Nanobody35 (17 kDa, Protein from synthetic construct)
- Cryo-em structure of the fenoldopam-bound d1r-minigs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Gbeta-1gama-2 (Complex from Homo sapiens)
- The fenoldopam-bound d1r-minigs (Complex)
Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7x2d
Q-score: 0.495
Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S
Nat Commun (2022) 13 pp. 3186-3186 [ Pubmed: 35676276 DOI: doi:10.1038/s41467-022-30929-w ]
- Tavapadon-bound d1r-minigs (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nanobody35 (17 kDa, Protein from synthetic construct)
- Cryo-em structure of the tavapadon-bound d1r-minigs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxy-phenyl]pyrimidine-2,4-dione (391 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- Nanobody35 (Complex)
Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7x2f
Q-score: 0.471
Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S
Nat Commun (2022) 13 pp. 3186-3186 [ Pubmed: 35676276 DOI: doi:10.1038/s41467-022-30929-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nanobody35 (17 kDa, Protein from synthetic construct)
- 2-[2,6-bis(chloranyl)phenyl]-1-[(1s,3r)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone (450 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Cryo-em structure of the dopamine-ly3154207-bound d1r-minigs complexthe (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (52 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Dopamine-ly3154207-bound d1r-minigs (Complex)
- Nanobody35 (Complex)
Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex.
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7ckw
Q-score: 0.431
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ Pubmed: 33571432 DOI: doi:10.1016/j.cell.2021.01.028 ]
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
- Nanobody 35 (Complex from Homo sapiens)
- Protein-1 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Lama glama)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Em stucture of complex-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7ckx
Q-score: 0.389
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ Pubmed: 33571432 DOI: doi:10.1016/j.cell.2021.01.028 ]
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- (1r,3s)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1h-isochromene-5,6-diol (329 Da, Ligand)
- Nanobody 35 (Complex from Lama glama)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Em structure of protein-2 (Complex)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7cky
Q-score: 0.254
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ Pubmed: 33571432 DOI: doi:10.1016/j.cell.2021.01.028 ]
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione (389 Da, Ligand)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Complex structure-3 (Complex)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ckz
Q-score: 0.451
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ Pubmed: 33571432 DOI: doi:10.1016/j.cell.2021.01.028 ]
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Complex structure-4 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- 2-[2,6-bis(chloranyl)phenyl]-1-[(1s,3r)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone (450 Da, Ligand)
Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7crh
Q-score: 0.419
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ Pubmed: 33571432 DOI: doi:10.1016/j.cell.2021.01.028 ]
- Nanobody35 (16 kDa, Protein from Lama glama)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- (1s)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol (317 Da, Ligand)
- Guanine nucleotide-binding protein alpha, beta-1 and gamma-2 (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Em structure of receptor signaling complex-5 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)