Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8vhf
Q-score: 0.449
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- The complex of gpr119-gs-nb35 (composite map) (177 kDa, Complex)
- Nanobody35 (15 kDa, Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (67 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, hibit (40 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- G-protein complex (93 kDa, Complex from Homo sapiens)
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982 (consensus map)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Gpr119-gs-nb35 complex (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- G-protein complex (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Nanobody35 (Protein from Lama glama)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- G-protein complex (Complex from Homo sapiens)
- Gpr119-gs-nb35 complex (Complex)
- Nanobody35 (Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Nanobody35 (Protein from Lama glama)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Gs-nb35 complex (110 kDa, Complex)
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
- Guanine nucleotide-bindign protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- G-protein complex (Complex from Homo sapiens)
- Gpr119-gs-nb35 complex (Complex)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Nanobody35 (Protein from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor gpr119 (Complex from Escherichia coli)
- Oea-gpr119-gs-nb35 complex (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Heterotrimeric gs protein (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor gpr119,lgbit (Protein from synthetic construct)
- Nanobody35 (Protein from Lama glama)
CryoEM structure of Gs-coupled GPBAR with small molecule agonist P395
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9gyo
Q-score: 0.629
Castel J, Botzanowski T, Brooks I, Frechard A, Bey G, Schroeter M, Del nero E, Debaene F, Ciesielski F, Zeyer D, Cianferani S, Morales R
To Be Published
- Complex of the tgr5 with gs protein heterotrimer, nanobody 35 and small molecule agonist p395 (Complex from Homo sapiens)
- 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5h-pyrido[4,3-d]pyrimidine-4-carboxamide (395 Da, Ligand)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,g-protein coupled bile acid receptor 1 (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
ADP-bound purinergic receptor 1 in complex with miniGs/q
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wjx
Q-score: 0.49
To Be Published
- Nanobody 35 (17 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Adp-bound purinergic receptor 1 in complex with minigs/q (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,p2y purinoceptor 1,soluble cytochrome b562,p2y purinoceptor 1 (76 kDa, Protein from Homo sapiens)
Structure of active state MC4R in complex with a potent ligand mimicking nanobody
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8qj2
Q-score: 0.431
Busch A, Jaakola V-P, Masiulis S
To Be Published
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Pn162 (12 kDa, Protein from Lama glama)
- Mc4r receptor in complex with gs protein heterotrimer, nanobody-35/confobody 35 and ligand-mimicking nanobody (Complex from Homo sapiens)
- Soluble cytochrome b562,melanocortin receptor 4,red fluorescent protein drfp583 (82 kDa, Protein from Discosoma sp.)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM Structure of GPR119-Gs-Firuglipel complex
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8zr5
Q-score: 0.505
To Be Published
- 4-[5-[(1~{r})-1-(4-cyclopropylcarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl]-2-fluoranyl-~{n}-[(2~{r})-1-oxidanylpropan-2-yl]benzamide (467 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs-firuglipel complex (Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist GSK-1292263
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8zrk
Q-score: 0.567
To Be Published
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody35 (17 kDa, Protein from synthetic construct)
- Gsk-1292263 (456 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucose-dependent insulinotropic receptor (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs complex with small molecule agonist gsk-1292263 (Complex from Homo sapiens)