Consensus olfactory receptor consOR51 in complex with mini-Gs trimeric protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8uxv
Q-score: 0.544
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Minigs399 (30 kDa, Protein from Homo sapiens)
- Consor51 (36 kDa, Protein from synthetic construct)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Consensus olfactory receptor consOR1 bound to L-menthol and in complex with mini-Gs trimeric protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8uxy
Q-score: 0.402
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Consor1 (35 kDa, Protein from synthetic construct)
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- (1r,2s,5r)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol (156 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Consensus olfactory receptor consOR2 bound to S-carvone and in complex with mini-Gs trimeric protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8uy0
Q-score: 0.489
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Minigs399 (30 kDa, Protein from Homo sapiens)
- Consor2-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Consor2 (35 kDa, Protein from synthetic construct)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- (5s)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one (150 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8uyq
Q-score: 0.262
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Consor4 (36 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Consor4-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (2r)-2-methyl-1,3-thiazolidine (103 Da, Ligand)
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982 (consensus map)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Gpr119-gs-nb35 complex (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- G-protein complex (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Nanobody35 (Protein from Lama glama)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- G-protein complex (Complex from Homo sapiens)
- Gpr119-gs-nb35 complex (Complex)
- Nanobody35 (Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Nanobody35 (Protein from Lama glama)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Gs-nb35 complex (110 kDa, Complex)
- Glucose-dependent insulinotropic receptor (Complex from Escherichia coli)
- Guanine nucleotide-bindign protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- G-protein complex (Complex from Homo sapiens)
- Gpr119-gs-nb35 complex (Complex)
- Nanobody35 (Complex from Lama glama)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Nanobody35 (Protein from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (Protein from synthetic construct)
- Guanine nucleotide-bindign protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor gpr119 (Complex from Escherichia coli)
- Oea-gpr119-gs-nb35 complex (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Heterotrimeric gs protein (Complex from Homo sapiens)
- Nanobody35 (Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor gpr119,lgbit (Protein from synthetic construct)
- Nanobody35 (Protein from Lama glama)
Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8yw3
Q-score: 0.514
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Cryo-em structure of the human glucagon-like peptide-1 receptor in complex with retatrutide and g protein (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8yw4
Q-score: 0.379
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Cryo-em structure of the retatrutide-bound human gipr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gastric inhibitory polypeptide receptor (65 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)