Cryo-EM structure of the PEA-bound mTAAR1-Gs complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wc6
Q-score: 0.542
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP
Cell (2023) 186 pp. 5347-5362.e24 [ DOI: doi:10.1016/j.cell.2023.10.014 Pubmed: 37963465 ]
- Trace amine-associated receptor 1 (37 kDa, Protein from Mus musculus)
- Cryo-em structure of the pea-bound mtaar1-gs complex (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- 2-phenylethylamine (122 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8itf
Q-score: 0.491
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ Pubmed: 37225986 DOI: doi:10.1038/s41586-023-06106-4 ]
- ~{n},~{n}-dimethylcyclohexanamine (127 Da, Ligand)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Cryo-em structure of the dmcha-bound mtaar9-gs complex (Complex from Mus musculus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8dcr
Q-score: 0.593
Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 4095-4095 [ DOI: doi:10.1038/s41467-022-31823-1 Pubmed: 35835792 ]
- Dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric gs-protein (Complex from Meleagris gallopavo)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Dobutamine (301 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Endolysin,endolysin,beta-1 adrenergic receptor chimera (57 kDa, Protein from Meleagris gallopavo)
Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex.
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7ckw
Q-score: 0.431
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Lama glama)
- Protein-1 (Complex)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Homo sapiens)
- Em stucture of complex-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7ckx
Q-score: 0.389
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- (1r,3s)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1h-isochromene-5,6-diol (329 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Em structure of protein-2 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7cky
Q-score: 0.254
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Complex structure-3 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione (389 Da, Ligand)
- Nanobody 35 (Complex from Lama glama)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ckz
Q-score: 0.451
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Complex structure-4 (Complex)
- 2-[2,6-bis(chloranyl)phenyl]-1-[(1s,3r)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone (450 Da, Ligand)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7jjo
Q-score: 0.599
Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY
Mol Cell (2020) 80 pp. 59- [ DOI: doi:10.1016/j.molcel.2020.08.001 Pubmed: 32818430 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric gs protein (160 kDa, Complex)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Isoprenaline (211 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Beta1-adrenergic receptor (Complex from Meleagris gallopavo)
- Nanobody 35 (Complex from Lama glama)
- Beta1-adrenergic receptor (57 kDa, Protein from Meleagris gallopavo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)