Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody
Resolution: 10.2 Å
EM Method: Single-particle
Fitted PDBs: 8fe3
Q-score: 0.059
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm12 fab heavy chain (24 kDa, Protein from Mus musculus)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
- Prm12 fab light chain (23 kDa, Protein from Mus musculus)
Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody
Resolution: 9.8 Å
EM Method: Single-particle
Fitted PDBs: 8fe4
Q-score: 0.062
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm13 fab heavy chain (23 kDa, Protein from Mus musculus)
- Prm13 fab light chain (23 kDa, Protein from Mus musculus)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
The mature Usutu SAAR-1776, Map A
Resolution: 2.42 Å
EM Method: Single-particle
Fitted PDBs: 7lcg
Q-score: 0.558
Khare B, Klose T, Fang Q, Rossmann MG, Kuhn RJ
PNAS (2021) 118 [ Pubmed: 34417300 DOI: doi:10.1073/pnas.2107408118 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope protein e (53 kDa, Protein from Usutu virus)
- Usutu virus (Virus from Usutu virus)
- Membrane protein m (8 kDa, Protein from Usutu virus)
- Trimethyl-[2-[[(2s,3s)-2-(octadecanoylamino)-3-oxidanyl-butoxy]-oxidanyl-phosphoryl]oxyethyl]azanium (537 Da, Ligand)
- (7s)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide (763 Da, Ligand)
The mature Usutu SAAR-1776, Map B
Resolution: 2.35 Å
EM Method: Single-particle
Fitted PDBs: 7lch
Q-score: 0.631
Khare B, Klose T, Fang Q, Rossmann MG, Kuhn RJ
PNAS (2021) 118 [ Pubmed: 34417300 DOI: doi:10.1073/pnas.2107408118 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope protein e (53 kDa, Protein from Usutu virus)
- Usutu virus (Virus from Usutu virus)
- Membrane protein m (8 kDa, Protein from Usutu virus)
- Trimethyl-[2-[[(2s,3s)-2-(octadecanoylamino)-3-oxidanyl-butoxy]-oxidanyl-phosphoryl]oxyethyl]azanium (537 Da, Ligand)
- (7s)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide (763 Da, Ligand)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7kcr
Q-score: 0.436
Sevvana M, Rogers TF, Miller AS, Long F, Klose T, Beutler N, Lai YC, Parren M, Walker LM, Buda G, Burton DR, Rossmann MG, Kuhn RJ
Viruses (2020) 12 [ Pubmed: 33255202 DOI: doi:10.3390/v12121346 ]
- Monoclonal antibody adi30056 (Complex from Homo sapiens)
- Envelope protein e (54 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Zika virus in complex with monoclonal antibody adi30056 (15 MDa, Complex)
- Zika virus zikv/h. sapiens/frenchpolynesia/10087pf/2013 (Virus from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Membrane protein m (8 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Adi30056 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- Adi30056 fab light chain variable region (11 kDa, Protein from Homo sapiens)
Cryo-EM Structure of Immature Zika Virus
Resolution: 9.1 Å
EM Method: Single-particle
Fitted PDBs: 5u4w
Q-score: 0.079
Prasad VM, Miller AS, Klose T, Sirohi D, Buda G, Jiang W, Kuhn RJ, Rossmann MG
Nat Struct Mol Biol (2017) 24 pp. 184-186 [ DOI: doi:10.1038/nsmb.3352 Pubmed: 28067914 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pr domain (9 kDa, Protein from Zika virus)
- E protein (44 kDa, Protein from Zika virus)
- Transmembrane domains (Complex from Zika virus)
- M protein (5 kDa, Protein from Zika virus)
- Zika virus (Virus from Zika virus)
- Protein e (6 kDa, Protein from Zika virus)