cryo-EM structure of zebrafish GPR4-Gs complex at pH 8.5
Ma Y, Wang Y, Tang M, Weng Y, Chen Y, Xu Y, An S, Wu Y, Zhao S, Xu H, Li D, Liu M, Lu W, Ru H, Song G
Nat Commun (2025) 16 pp. 605-605 [ DOI: doi:10.1038/s41467-025-55901-2 Pubmed: 39799123 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Mus musculus)
- Zgpr4-gs complex (Complex from Danio rerio)
- Soluble cytochrome b562,g-protein coupled receptor 4,lgbit (72 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8yh0
Q-score: 0.442
Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 9294-9294 [ Pubmed: 39511145 DOI: doi:10.1038/s41467-024-53473-1 ]
- Scfv16 (27 kDa, Protein from Mus musculus)
- Ha tag,adenosine receptor a3,lgbit,egfp chimera (88 kDa, Protein from Ovis aries)
- N-ethyl-5'-carboxamido adenosine (308 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 (48 kDa, Protein from Homo sapiens)
- A3r-gi complex bound to neca (Complex from Ovis aries)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
A3R-Gi complex bound to adenosine
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8yh2
Q-score: 0.379
Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 9294-9294 [ Pubmed: 39511145 DOI: doi:10.1038/s41467-024-53473-1 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera (48 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- A3r-gi complex bound to adenosine (Complex from Ovis aries)
- Adenosine (267 Da, Ligand)
- Hemagglutinin,adenosine receptor a3,gfp chimera (88 kDa, Protein from Human orthopneumovirus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8yh3
Q-score: 0.323
Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 9294-9294 [ Pubmed: 39511145 DOI: doi:10.1038/s41467-024-53473-1 ]
- N-methyladenosine (281 Da, Ligand)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera (48 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
- A3r-gi complex bound to m6a (Complex from Ovis aries)
- Hemagglutinin,adenosine receptor a3,gfp chimera (88 kDa, Protein from human respiratory syncytial virus)
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 8yh5
Q-score: 0.326
Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 9294-9294 [ Pubmed: 39511145 DOI: doi:10.1038/s41467-024-53473-1 ]
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera (48 kDa, Protein from Bos taurus)
- N-(3-methylbut-2-en-1-yl)adenosine (335 Da, Ligand)
- A3r-gi complex bound to i6a (Complex from Ovis aries)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
- Hemagglutinin,adenosine receptor a3,gfp chimera (88 kDa, Protein from human respiratory syncytial virus)
A3R-Gi complex bound to namodenoson
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8yh6
Q-score: 0.275
Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 9294-9294 [ Pubmed: 39511145 DOI: doi:10.1038/s41467-024-53473-1 ]
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 chimera (48 kDa, Protein from Bos taurus)
- A3r-gi complex bound to namodenoson (Complex from Ovis aries)
- Namodenoson (544 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
- Hemagglutinin,adenosine receptor a3,gfp chimera (88 kDa, Protein from human respiratory syncytial virus)
Cryo-EM structure of ET-1 bound ETBR-DNGI complex
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8xwp
Q-score: 0.454
Tani K, Maki-Yonekura S, Kanno R, Negami T, Hamaguchi T, Hall M, Mizoguchi A, Humbel BM, Terada T, Yonekura K, Doi T
Commun Biol (2024) 7 pp. 1303-1303 [ DOI: doi:10.1038/s42003-024-06905-z Pubmed: 39414992 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Et-1 bound etbr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Scfv16 (29 kDa, Protein from Mus musculus)
- Endothelin receptor type b (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of ET-1 bound ETBR-DNGI complex
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 8xwq
Q-score: 0.29
Tani K, Maki-Yonekura S, Kanno R, Negami T, Hamaguchi T, Hall M, Mizoguchi A, Humbel BM, Terada T, Yonekura K, Doi T
Commun Biol (2024) 7 pp. 1303-1303 [ DOI: doi:10.1038/s42003-024-06905-z Pubmed: 39414992 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Et-1 bound etbr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Scfv16 (29 kDa, Protein from Mus musculus)
- Endothelin receptor type b (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of Melanin-Concentrating Hormone Receptor 1 with MCH
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8wss
Q-score: 0.495
He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 48-48 [ DOI: doi:10.1038/s41421-024-00679-8 Pubmed: 38710677 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors1 (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Melanin-concentrating hormone receptor 1 (43 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Pro-mch (2 kDa, Protein from Homo sapiens)
Structural insights into human brain gut peptide cholecystokinin receptors
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ia7
Q-score: 0.522
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell Discov (2022) 8 pp. 55-55 [ DOI: doi:10.1038/s41421-022-00420-3 Pubmed: 35672283 ]
- Gastrin/cholecystokinin type b receptor (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G subunit q (gi1-gq chimeric) (Complex from Homo sapiens)
- Cck-8 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Human brain gut peptide cholecystokinin receptors (Complex)
- Cck-8 (Complex)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholecystokinin receptor (Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)