Paltusotine-bound SSTR2-Gi complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7yac
Q-score: 0.477
Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z
Nat Commun (2023) 14 pp. 962-962 [ Pubmed: 36810324 DOI: doi:10.1038/s41467-023-36673-z ]
- Paltusotine (456 Da, Ligand)
- Guanine nucleotide-binding protein, somatostatin receptor 2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Paltusotine-bound somatostatin receptor 2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
Octreotide-bound SSTR2-Gi complex
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 7yae
Q-score: 0.382
Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z
Nat Commun (2023) 14 pp. 962-962 [ Pubmed: 36810324 DOI: doi:10.1038/s41467-023-36673-z ]
- Somatostatin receptor type 2 (42 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 2 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Dpn-cys-phe-dtr-lys-thr-cys-tho (1 kDa, Protein from synthetic construct)
- Dpn-cys-phe-dtr-lys-thr-cys-tho (Complex)
- Cholesterol (386 Da, Ligand)
- Octreotide-bound somatostatin receptor 2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Scfv16 (27 kDa, Protein from Mus musculus)
Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7y24
Q-score: 0.442
Nat Chem Biol (2023) 19 pp. 133-140 [ Pubmed: 36138141 DOI: doi:10.1038/s41589-022-01130-3 ]
- Svfv16, octreotide (Complex from Homo sapiens)
- Octreotide (1 kDa, Protein from Homo sapiens)
- G(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Complex of sstr2-minigo-scfv16 bound with octreotide (Complex from Homo sapiens)
- Single fab chain (svfv16) (26 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (36 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (Complex)
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7y26
Q-score: 0.468
Nat Chem Biol (2023) 19 pp. 133-140 [ Pubmed: 36138141 DOI: doi:10.1038/s41589-022-01130-3 ]
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Single fab chain (svfv16) (27 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Octreotide (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Octreotide (Complex)
- Complex of sstr2-minigq-scfv16 bound with octreotide (Complex from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- G(q) subunit alpha, sstr2, svfv16 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7y27
Q-score: 0.464
Nat Chem Biol (2023) 19 pp. 133-140 [ Pubmed: 36138141 DOI: doi:10.1038/s41589-022-01130-3 ]
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Complex of sstr2-minigq-scfv16 bound with sst-14 (Complex from Homo sapiens)
- Single fab chain (svfv16) (27 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Sst-14 (Complex)
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- G(q) subunit alpha, sstr2, svfv16 (Complex)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
Structure of somatostatin receptor 2 bound with SST14.
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7xat
Q-score: 0.545
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ DOI: doi:10.1038/s41421-022-00405-2 Pubmed: 35595746 ]
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
- The endogenous ligand sst14-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Structure of somatostatin receptor 2 bound with octreotide.
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7xau
Q-score: 0.49
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ DOI: doi:10.1038/s41421-022-00405-2 Pubmed: 35595746 ]
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Octreotide (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The sst anologue octreotide bound somatostatin receptor 2 and gi heterotrimer complex (Complex from Homo sapiens)
Structure of somatostatin receptor 2 bound with lanreotide.
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7xav
Q-score: 0.514
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ DOI: doi:10.1038/s41421-022-00405-2 Pubmed: 35595746 ]
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
- Lanreotide (1 kDa, Protein from synthetic construct)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The sst analogue lanreotide-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xmr
Q-score: 0.41
Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q
Cell Res (2022) 32 pp. 761-772 [ DOI: doi:10.1038/s41422-022-00679-x Pubmed: 35739238 ]
- Somatostatin receptor type 2 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Complex structure of the somatostatin receptor 2 (sstr2) in complex with gi1 and its endogeneous peptide ligand sst-14 (Complex from Homo sapiens)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 7wj5
Q-score: 0.485
Heo Y, Yoon E, Jeon YE, Yun JH, Ishimoto N, Woo H, Park SY, Song JJ, Lee W
eLife (2022) 11 [ DOI: doi:10.7554/eLife.76823 Pubmed: 35446253 ]
- Soluble cytochrome b562,somatostatin receptor type 2 (58 kDa, Protein from Homo sapiens)
- Somatostatin-14 (sst-14) (1 kDa, Protein from Homo sapiens)
- Gai1 antibody (scfv16) (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Human sstr2 and sst-14 complex (Complex from Homo sapiens)