Paltusotine-bound SSTR2-Gi complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7yac
Q-score: 0.477
Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z
Nat Commun (2023) 14 pp. 962-962 [ Pubmed: 36810324 DOI: doi:10.1038/s41467-023-36673-z ]
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Paltusotine-bound somatostatin receptor 2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein, somatostatin receptor 2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Paltusotine (456 Da, Ligand)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
Octreotide-bound SSTR2-Gi complex
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 7yae
Q-score: 0.382
Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z
Nat Commun (2023) 14 pp. 962-962 [ Pubmed: 36810324 DOI: doi:10.1038/s41467-023-36673-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 2 (Complex)
- Somatostatin receptor type 2 (42 kDa, Protein from Homo sapiens)
- Dpn-cys-phe-dtr-lys-thr-cys-tho (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Dpn-cys-phe-dtr-lys-thr-cys-tho (1 kDa, Protein from synthetic construct)
- Octreotide-bound somatostatin receptor 2 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7y24
Q-score: 0.442
Nat Chem Biol (2023) 19 pp. 133-140 [ DOI: doi:10.1038/s41589-022-01130-3 Pubmed: 36138141 ]
- Complex of sstr2-minigo-scfv16 bound with octreotide (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Single fab chain (svfv16) (26 kDa, Protein from Homo sapiens)
- Svfv16, octreotide (Complex from Homo sapiens)
- Octreotide (1 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (Complex)
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- Somatostatin receptor type 2 (36 kDa, Protein from Homo sapiens)
Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7y26
Q-score: 0.468
Nat Chem Biol (2023) 19 pp. 133-140 [ DOI: doi:10.1038/s41589-022-01130-3 Pubmed: 36138141 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Single fab chain (svfv16) (27 kDa, Protein from Homo sapiens)
- Octreotide (Complex)
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Octreotide (1 kDa, Protein from Homo sapiens)
- G(q) subunit alpha, sstr2, svfv16 (Complex)
- Complex of sstr2-minigq-scfv16 bound with octreotide (Complex from Homo sapiens)
Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7y27
Q-score: 0.464
Nat Chem Biol (2023) 19 pp. 133-140 [ DOI: doi:10.1038/s41589-022-01130-3 Pubmed: 36138141 ]
- Engineered guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (37 kDa, Protein from Homo sapiens)
- Single fab chain (svfv16) (27 kDa, Protein from Homo sapiens)
- Complex of sstr2-minigq-scfv16 bound with sst-14 (Complex from Homo sapiens)
- Sst-14 (Complex)
- G(i)/g(s)/g(t) subunit beta-1, g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- G(q) subunit alpha, sstr2, svfv16 (Complex)
Structure of somatostatin receptor 2 bound with SST14.
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7xat
Q-score: 0.545
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ Pubmed: 35595746 DOI: doi:10.1038/s41421-022-00405-2 ]
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The endogenous ligand sst14-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
Structure of somatostatin receptor 2 bound with octreotide.
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7xau
Q-score: 0.49
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ Pubmed: 35595746 DOI: doi:10.1038/s41421-022-00405-2 ]
- The sst anologue octreotide bound somatostatin receptor 2 and gi heterotrimer complex (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Octreotide (1 kDa, Protein from synthetic construct)
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
Structure of somatostatin receptor 2 bound with lanreotide.
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7xav
Q-score: 0.514
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ Pubmed: 35595746 DOI: doi:10.1038/s41421-022-00405-2 ]
- The sst analogue lanreotide-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Lanreotide (1 kDa, Protein from synthetic construct)
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xmr
Q-score: 0.41
Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q
Cell Res (2022) 32 pp. 761-772 [ Pubmed: 35739238 DOI: doi:10.1038/s41422-022-00679-x ]
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Complex structure of the somatostatin receptor 2 (sstr2) in complex with gi1 and its endogeneous peptide ligand sst-14 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2 (45 kDa, Protein from Homo sapiens)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 7wj5
Q-score: 0.485
Heo Y, Yoon E, Jeon YE, Yun JH, Ishimoto N, Woo H, Park SY, Song JJ, Lee W
eLife (2022) 11 [ DOI: doi:10.7554/eLife.76823 Pubmed: 35446253 ]
- Human sstr2 and sst-14 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gai1 antibody (scfv16) (28 kDa, Protein from Homo sapiens)
- Somatostatin-14 (sst-14) (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,somatostatin receptor type 2 (58 kDa, Protein from Homo sapiens)