Resolution: 2.08 Å
EM Method: Single-particle
Fitted PDBs: 8q3v
Q-score: 0.686
Aziz I, Kayastha K, Kaltwasser S, Vonck J, Welsch S, Murphy BJ, Kahnt J, Wu D, Wagner T, Shima S, Ermler U
PNAS (2024) 121 pp. e2315568121-e2315568121 [ DOI: doi:10.1073/pnas.2315568121 Pubmed: 38530900 ]
- Tetrahydromethanopterin s-methyltransferase subunit d (22 kDa, Protein from Methanothermobacter marburgensis)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Tetrahydromethanopterin s-methyltransferase subunit a 1 (25 kDa, Protein from Methanothermobacter marburgensis)
- Tetrahydromethanopterin s-methyltransferase subunit e (31 kDa, Protein from Methanothermobacter marburgensis)
- Magnesium ion (24 Da, Ligand)
- Methyl-h4mpt:com methyltransferase (430 MDa, Complex from Methanothermobacter marburgensis)
- Tetrahydromethanopterin s-methyltransferase subunit g (9 kDa, Protein from Methanothermobacter marburgensis)
- [(2~{s},7~{r},11~{r},15~{s},19~{s},22~{s},26~{s},30~{r},34~{r},39~{s},43~{r},47~{r},51~{s},55~{s},58~{s},62~{s},66~{r},70~{r})-39-[[(2~{r},3~{r},4~{s},5~{s},6~{r})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methyl [(2~{r},3~{s},5~{r},6~{r})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl] hydrogen phosphate (1 kDa, Ligand)
- Tetrahydromethanopterin s-methyltransferase subunit f (7 kDa, Protein from Methanothermobacter marburgensis)
- Tetrahydromethanopterin s-methyltransferase subunit c (27 kDa, Protein from Methanothermobacter marburgensis)
- Tetrahydromethanopterin s-methyltransferase subunit b (10 kDa, Protein from Methanothermobacter marburgensis)
Sodium pumping NADH-quinone oxidoreductase with substrates NADH and Q2
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8a1u
Q-score: 0.558
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ Pubmed: 37710014 DOI: doi:10.1038/s41594-023-01099-0 ]
- Riboflavin (376 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Ubiquinone-2 (318 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (51 kDa, Protein from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- 1,4-dihydronicotinamide adenine dinucleotide (665 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nqr complex with substrates nadh and q2 (220 kDa, Complex from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
Sodium pumping NADH-quinone oxidoreductase
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8a1t
Q-score: 0.452
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ DOI: doi:10.1038/s41594-023-01099-0 Pubmed: 37710014 ]
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Riboflavin (376 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
- Flavin mononucleotide (456 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (48 kDa, Protein from Vibrio cholerae)
- Nqr complex (220 kDa, Complex from Vibrio cholerae)
- Sodium ion (22 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
Sodium pumping NADH-quinone oxidoreductase with substrate Q2
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8a1v
Q-score: 0.54
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ Pubmed: 37710014 DOI: doi:10.1038/s41594-023-01099-0 ]
- Riboflavin (376 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Ubiquinone-2 (318 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (51 kDa, Protein from Vibrio cholerae)
- Nqr complex with substrate q2 (220 kDa, Complex from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
Sodium pumping NADH-quinone oxidoreductase with substrate Q1
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8a1w
Q-score: 0.555
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ DOI: doi:10.1038/s41594-023-01099-0 Pubmed: 37710014 ]
- Ubiquinone-1 (250 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Water (18 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Riboflavin (376 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (51 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
- Flavin mononucleotide (456 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Nqr complex with substrate q1 (220 kDa, Complex from Vibrio cholerae)
Sodium pumping NADH-quinone oxidoreductase with inhibitor DQA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8a1x
Q-score: 0.467
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ Pubmed: 37710014 DOI: doi:10.1038/s41594-023-01099-0 ]
- Riboflavin (376 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Flavin mononucleotide (456 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (48 kDa, Protein from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Nqr complex with inhibitor dqa (220 kDa, Complex from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)
Sodium pumping NADH-quinone oxidoreductase with inhibitor HQNO
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8a1y
Q-score: 0.426
Hau JL, Kaltwasser S, Muras V, Casutt MS, Vohl G, Claussen B, Steffen W, Leitner A, Bill E, Cutsail 3rd GE, DeBeer S, Vonck J, Steuber J, Fritz G
Nat Struct Mol Biol (2023) 30 pp. 1686-1694 [ Pubmed: 37710014 DOI: doi:10.1038/s41594-023-01099-0 ]
- Riboflavin (376 Da, Ligand)
- 2-heptyl-4-hydroxy quinoline n-oxide (259 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit b (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit f (45 kDa, Protein from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit d (22 kDa, Protein from Vibrio cholerae)
- Flavin mononucleotide (456 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit a (51 kDa, Protein from Vibrio cholerae)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Na(+)-translocating nadh-quinone reductase subunit c (27 kDa, Protein from Vibrio cholerae)
- Nqr complex with inhibitor hqno (220 kDa, Complex from Vibrio cholerae)
- Na(+)-translocating nadh-quinone reductase subunit e (21 kDa, Protein from Vibrio cholerae)