Yeast V-ATPase Vo proton channel bound to nanobody 1WVA25
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9e76
Q-score: 0.507
Knight K, Park JB, Oot RA, Khan MM, Roh SH, Wilkens S
bioRxiv (2025) [ Pubmed: 39829782 DOI: doi:10.1101/2025.01.10.632502 ]
- V-type proton atpase subunit d (39 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase subunit c'' (22 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase subunit a, vacuolar isoform (95 kDa, Protein from Saccharomyces cerevisiae)
- V0 assembly protein 1 (29 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase subunit c (16 kDa, Protein from Saccharomyces cerevisiae)
- Nanobody 1wva25 (16 kDa, Protein from Lama glama)
- V-type proton atpase subunit c' (17 kDa, Protein from Saccharomyces cerevisiae)
- Yeast v-atpase vo proton channel subcomplex bound to nanobody 1wva25 (400 kDa, Complex from Saccharomyces cerevisiae)
- V-type proton atpase subunit e (8 kDa, Protein from Saccharomyces cerevisiae)
- Yeast v-atpase subunit f (9 kDa, Protein from Saccharomyces cerevisiae)
Yeast RAVE bound to V-ATPase V1 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9cop
Q-score: 0.252
Wang H, Tarsio M, Kane PM, Rubinstein JL
PNAS (2024) 121 pp. e2414511121-e2414511121 [ Pubmed: 39625975 DOI: doi:10.1073/pnas.2414511121 ]
- V-type proton atpase subunit f (13 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase subunit e (26 kDa, Protein from Saccharomyces cerevisiae)
- Regulator of v-atpase in vacuolar membrane protein 2 (40 kDa, Protein from Saccharomyces cerevisiae)
- Suppressor of kinetochore protein 1 (22 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase subunit h (54 kDa, Protein from Saccharomyces cerevisiae)
- Regulator of v-atpase in vacuolar membrane protein 1 (155 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase subunit g (12 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase catalytic subunit a (118 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Yeast rave bound to v-atpase v1 complex (Complex from Saccharomyces cerevisiae)
- V-type proton atpase subunit b (57 kDa, Protein from Saccharomyces cerevisiae)
- V-type proton atpase subunit d (29 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 9bcu
Q-score: 0.613
You L, Wang C, Molodtsov V, Kuznedelov K, Miao X, Wenck BR, Ulisse P, Sanders TJ, Marshall CJ, Firlar E, Kaelber JT, Santangelo TJ, Ebright RH
Nature (2024) 635 pp. 229-236 [ DOI: doi:10.1038/s41586-024-07979-9 Pubmed: 39322680 ]
- Transcription elongation factor spt5 (16 kDa, Protein from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit d (29 kDa, Protein from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit n (7 kDa, Protein from Thermococcus kodakarensis)
- Rna (29-mer) (16 kDa, RNA from synthetic construct)
- Dna-directed rna polymerase subunit a" (43 kDa, Protein from Thermococcus kodakarensis)
- Zinc ion (65 Da, Ligand)
- Non-template strand dna (11 kDa, DNA from synthetic construct)
- Transcription elongation factor spt4 (8 kDa, Protein from Thermococcus kodakarensis)
- Ftta-dependent transcription termination complex containing 52 nt rna (556 kDa, Complex from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit e (21 kDa, Protein from Thermococcus kodakarensis)
- Template strand dna (11 kDa, DNA from synthetic construct)
- Dna-directed rna polymerase subunit l (11 kDa, Protein from Thermococcus kodakarensis)
- Transcription termination factor ftta (73 kDa, Protein from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit f (14 kDa, Protein from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit k (6 kDa, Protein from Thermococcus kodakarensis)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase subunit p (5 kDa, Protein from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit h (9 kDa, Protein from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit b (127 kDa, Protein from Thermococcus kodakarensis)
- Dna-directed rna polymerase subunit a' (103 kDa, Protein from Thermococcus kodakarensis)
Structure of the human ATP synthase bound to bedaquiline (membrane domain)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8khf
Q-score: 0.508
Zhang Y, Lai Y, Zhou S, Ran T, Zhang Y, Zhao Z, Feng Z, Yu L, Xu J, Shi K, Wang J, Pang Y, Li L, Chen H, Guddat LW, Gao Y, Liu F, Rao Z, Gong H
Nature (2024) 631 pp. 409-414 [ DOI: doi:10.1038/s41586-024-07605-8 Pubmed: 38961288 ]
- Atp synthase subunit f, mitochondrial (10 kDa, Protein from Homo sapiens)
- Atp synthase subunit a (24 kDa, Protein from Homo sapiens)
- Atp synthase protein 8 (8 kDa, Protein from Homo sapiens)
- Bedaquiline (555 Da, Ligand)
- Atp synthase f(0) complex subunit c1, mitochondrial (7 kDa, Protein from Homo sapiens)
- Atp synthase f(0) complex subunit b1, mitochondrial (24 kDa, Protein from Homo sapiens)
- Human atp synthase (Complex from Homo sapiens)
- Atp synthase subunit atp5mj, mitochondrial (6 kDa, Protein from Homo sapiens)
- Atp synthase subunit g, mitochondrial (11 kDa, Protein from Homo sapiens)
- Atp synthase subunit e, mitochondrial (7 kDa, Protein from Homo sapiens)
- Atp synthase subunit d, mitochondrial (18 kDa, Protein from Homo sapiens)
- Atp synthase subunit epsilon, mitochondrial (5 kDa, Protein from Homo sapiens)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from Homo sapiens)
- Atp synthase subunit delta, mitochondrial (15 kDa, Protein from Homo sapiens)
Structure of the human ATP synthase bound to bedaquiline (composite)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8ki3
Q-score: 0.547
Zhang Y, Lai Y, Zhou S, Ran T, Zhang Y, Zhao Z, Feng Z, Yu L, Xu J, Shi K, Wang J, Pang Y, Li L, Chen H, Guddat LW, Gao Y, Liu F, Rao Z, Gong H
Nature (2024) 631 pp. 409-414 [ DOI: doi:10.1038/s41586-024-07605-8 Pubmed: 38961288 ]
- Atpase inhibitor, mitochondrial (9 kDa, Protein from Homo sapiens)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from Homo sapiens)
- Human atp synthase (Complex from Homo sapiens)
- Atp synthase subunit atp5mj, mitochondrial (6 kDa, Protein from Homo sapiens)
- Atp synthase subunit e, mitochondrial (7 kDa, Protein from Homo sapiens)
- Atp synthase subunit d, mitochondrial (18 kDa, Protein from Homo sapiens)
- Atp synthase subunit g, mitochondrial (11 kDa, Protein from Homo sapiens)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from Homo sapiens)
- Atp synthase-coupling factor 6, mitochondrial (12 kDa, Protein from Homo sapiens)
- Atp synthase subunit a (24 kDa, Protein from Homo sapiens)
- Atp synthase f(0) complex subunit c1, mitochondrial (7 kDa, Protein from Homo sapiens)
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from Homo sapiens)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit epsilon, mitochondrial (5 kDa, Protein from Homo sapiens)
- Atp synthase subunit f, mitochondrial (10 kDa, Protein from Homo sapiens)
- Atp synthase protein 8 (8 kDa, Protein from Homo sapiens)
- Bedaquiline (555 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp synthase f(0) complex subunit b1, mitochondrial (24 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit delta, mitochondrial (15 kDa, Protein from Homo sapiens)
Yeast ATP synthase map in conformation-1 at pH 6
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8f29
Q-score: 0.301
Sharma S, Luo M, Patel H, Mueller DM, Liao M
Nat Struct Mol Biol (2024) 31 pp. 657-666 [ DOI: doi:10.1038/s41594-024-01219-4 Pubmed: 38316880 ]
- Atp synthase subunit a (25 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit alpha, mitochondrial (54 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit h, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 5, mitochondrial (20 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 4, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit d, mitochondrial (19 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit gamma, mitochondrial (28 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit j, mitochondrial (4 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit beta, mitochondrial (50 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit delta, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 9, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase (Complex from Saccharomyces cerevisiae)
- Atp synthase subunit f, mitochondrial (9 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase protein 8 (5 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Atp synthase subunit epsilon, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Yeast ATP synthase map in conformation-2, at pH 6
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8f39
Q-score: 0.301
Sharma S, Luo M, Patel H, Mueller DM, Liao M
Nat Struct Mol Biol (2024) 31 pp. 657-666 [ DOI: doi:10.1038/s41594-024-01219-4 Pubmed: 38316880 ]
- Atp synthase subunit a (25 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 5, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit alpha, mitochondrial (54 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit h, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit beta, mitochondrial (50 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit d, mitochondrial (19 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit j, mitochondrial (4 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit gamma, mitochondrial (29 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 9, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase protein 8 (5 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase (Complex from Saccharomyces cerevisiae)
- Atp synthase subunit f, mitochondrial (9 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit delta, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Atp synthase subunit 4, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit epsilon, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Yeast ATP Synthase in conformation-3, at pH 6
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8fkj
Q-score: 0.321
Sharma S, Luo M, Patel H, Mueller DM, Liao M
Nat Struct Mol Biol (2024) 31 pp. 657-666 [ DOI: doi:10.1038/s41594-024-01219-4 Pubmed: 38316880 ]
- Atp synthase subunit gamma (29 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 5, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit a (25 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit alpha (54 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 9, mitochondrial (7 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit h, mitochondrial (10 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit d, mitochondrial (19 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit delta, mitochondrial (14 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase protein 8 (5 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase (Complex from Saccharomyces cerevisiae)
- Atp synthase subunit f, mitochondrial (9 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit 4, mitochondrial (17 kDa, Protein from Saccharomyces cerevisiae)
- Atp18 isoform 1 (4 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit epsilon, mitochondrial (6 kDa, Protein from Saccharomyces cerevisiae)
- Atp synthase subunit beta (50 kDa, Protein from Saccharomyces cerevisiae)
Rat Kidney V-ATPase with SidK, State 1
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7uzf
Q-score: 0.332
To Be Published
- V-type proton atpase 116 kda subunit a isoform 1 (96 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Rattus norvegicus)
- Ribonuclease k (11 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit f (13 kDa, Protein from Rattus norvegicus)
- Atpase, h+ transporting, v0 subunit b (predicted), isoform cra_a (21 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit g (13 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit h (55 kDa, Protein from Rattus norvegicus)
- Rat kidney v-atpase with sidk (Complex from Rattus norvegicus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Rattus norvegicus)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Rattus norvegicus)
- Effector sidk (32 kDa, Protein from Legionella pneumophila)
- Renin receptor (39 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Rattus norvegicus)
- Atpase h+-transporting v1 subunit d (28 kDa, Protein from Rattus norvegicus)
- Atpase h+-transporting v1 subunit a (68 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit (40 kDa, Protein from Rattus norvegicus)
Rat Kidney V-ATPase lacking subunit H, with SidK and NCOA7B, State 1
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uzg
Q-score: 0.35
To Be Published
- V-type proton atpase 116 kda subunit a isoform 1 (96 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Rattus norvegicus)
- Ribonuclease k (11 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit f (13 kDa, Protein from Rattus norvegicus)
- Atpase, h+ transporting, v0 subunit b (predicted), isoform cra_a (21 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit g (13 kDa, Protein from Rattus norvegicus)
- Legionella pneumophila effector sidk (34 kDa, Protein from Legionella pneumophila)
- Rat kidney v-atpase with sidk (Complex from Rattus norvegicus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Rattus norvegicus)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Rattus norvegicus)
- Renin receptor (39 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Rattus norvegicus)
- Atpase h+-transporting v1 subunit d (28 kDa, Protein from Rattus norvegicus)
- Nuclear receptor coactivator 7 (19 kDa, Protein from Rattus norvegicus)
- Atpase h+-transporting v1 subunit a (68 kDa, Protein from Rattus norvegicus)
- V-type proton atpase subunit (40 kDa, Protein from Rattus norvegicus)