Structure of the human 48S initiation complex in open state (h48S AUG open)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7qp6
Q-score: 0.233
Yi SH, Petrychenko V, Schliep JE, Goyal A, Linden A, Chari A, Urlaub H, Stark H, Rodnina MV, Adio S, Fischer N
Nucleic Acids Res (2022) 50 pp. 5282-5298 [ DOI: doi:10.1093/nar/gkac283 Pubmed: 35489072 ]
- Human 48s initiation complex 40s-eif1-eif1a-eif2-eif3-trna-met-mrna (Complex)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Mrna (6 kDa, RNA from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 2 (38 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Eukaryotic translation initiation factor 3 subunit f (37 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit g (35 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit d (64 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- 18s rrna (603 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit a (166 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit c (105 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit b (92 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 1 (12 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 1a, x-chromosomal (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 3 (51 kDa, Protein from Homo sapiens)
- Initiator met-trna-i (24 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Homo sapiens)
55S mammalian mitochondrial ribosome with mtEFG1 and two tRNAMet (TI-POST)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6ydw
Q-score: 0.31
EMBO J (2020) 39 pp. e104820-e104820 [ Pubmed: 32602580 DOI: doi:10.15252/embj.2020104820 ]
- Mitochondrial ribosomal protein s22 (43 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s25 (19 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l20 (17 kDa, Protein from Sus scrofa)
- Uncharacterized protein (21 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l43 (17 kDa, Protein from Sus scrofa)
- Uncharacterized protein (15 kDa, Protein from Sus scrofa)
- Elongation factor g, mitochondrial (Complex from Homo sapiens)
- Mitochondrial ribosomal protein l50 (22 kDa, Protein from Sus scrofa)
- Uncharacterized protein (20 kDa, Protein from Sus scrofa)
- Uncharacterized protein (24 kDa, Protein from Sus scrofa)
- Ms34 (25 kDa, Protein from Sus scrofa)
- Uncharacterized protein (19 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s31 (44 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l12 (21 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s12 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s5 (48 kDa, Protein from Sus scrofa)
- Uncharacterized protein (25 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l46 (32 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s18a (22 kDa, Protein from Sus scrofa)
- Uncharacterized protein (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s35 (37 kDa, Protein from Sus scrofa)
- Trnamet and mrna (Complex from Homo sapiens)
- Uncharacterized protein (17 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l45 (35 kDa, Protein from Sus scrofa)
- Ms23 (21 kDa, Protein from Sus scrofa)
- Uncharacterized protein (24 kDa, Protein from Sus scrofa)
- Unknown peptide (1 kDa, Protein from Sus scrofa)
- Uncharacterized protein (7 kDa, Protein from Sus scrofa)
- Cp trna-phe (23 kDa, RNA from Sus scrofa)
- Uncharacterized protein (37 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l11 (20 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Mitochondrial ribosomal protein s7 (28 kDa, Protein from Sus scrofa)
- Uncharacterized protein (30 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s16, mitochondrial (15 kDa, Protein from Sus scrofa)
- Spermine (202 Da, Ligand)
- Uncharacterized protein (24 kDa, Protein from Sus scrofa)
- Elongation factor g, mitochondrial (80 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18 (20 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l9 (30 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l38 (44 kDa, Protein from Sus scrofa)
- Uncharacterized protein (28 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l37 (47 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l39 (38 kDa, Protein from Sus scrofa)
- 55s s. scrofa mitochondrial ribosome in complex with mtefg1, two trna-met and cugaug mrna (2 MDa, Complex)
- Us11m (20 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l34 (10 kDa, Protein from Sus scrofa)
- Ms37 (13 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l51 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s18c (16 kDa, Protein from Sus scrofa)
- Guanosine-5'-monophosphate (363 Da, Ligand)
- Mitochondrial ribosomal protein l4 (33 kDa, Protein from Sus scrofa)
- Uncharacterized protein (16 kDa, Protein from Sus scrofa)
- Us15m (27 kDa, Protein from Sus scrofa)
- Uncharacterized protein (18 kDa, Protein from Sus scrofa)
- Uncharacterized protein (15 kDa, Protein from Sus scrofa)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ml53 (12 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s2 (31 kDa, Protein from Sus scrofa)
- Trnamet (22 kDa, RNA from Homo sapiens)
- Mitochondrial ribosomal protein s10 (23 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l21 (23 kDa, Protein from Sus scrofa)
- Death associated protein 3 (46 kDa, Protein from Sus scrofa)
- Ms39 (78 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l28 (30 kDa, Protein from Sus scrofa)
- Uncharacterized protein (23 kDa, Protein from Sus scrofa)
- N-formylmethionine (177 Da, Ligand)
- Mitochondrial ribosomal protein s14 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l57 (12 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l41 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s24 (18 kDa, Protein from Sus scrofa)
- Uncharacterized protein (45 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s27 (51 kDa, Protein from Sus scrofa)
- Mrna (1 kDa, RNA from Homo sapiens)
- 12s rrna (5 MDa, RNA from Sus scrofa)
- Mitochondrial ribosomal protein l27 (15 kDa, Protein from Sus scrofa)
- Uncharacterized protein (33 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s18b, mitochondrial (29 kDa, Protein from Sus scrofa)
- Ribosomal protein (10 kDa, Protein from Sus scrofa)
- Ms33 (12 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l48, mitochondrial (29 kDa, Protein from Sus scrofa)
- Uncharacterized protein (13 kDa, Protein from Sus scrofa)
- Bs21m (10 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l47 (30 kDa, Protein from Sus scrofa)
- Mitoribosomal protein ms28, mrps28 (21 kDa, Protein from Sus scrofa)
- Ict1 (38 kDa, Protein from Sus scrofa)
- Aurora kinase a interacting protein 1 (22 kDa, Protein from Sus scrofa)
- 55s s. scrofa mitochondrial ribosome (Complex from Sus scrofa)
- Mitochondrial ribosomal protein l35 (21 kDa, Protein from Sus scrofa)
- Water (18 Da, Ligand)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- 39s ribosomal protein s30, mitochondrial (49 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l19 (33 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s26 (23 kDa, Protein from Sus scrofa)
- Us17m (14 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l10 (29 kDa, Protein from Sus scrofa)
- Mrpl34 (18 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Uncharacterized protein (33 kDa, Protein from Sus scrofa)