Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8z7r
Q-score: 0.517
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Slc19a3 (Complex from Homo sapiens)
SLC19A3-thiamine outward structure
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8z7s
Q-score: 0.541
SLC19A3-Pyridoxine outward structure
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8z7t
Q-score: 0.492
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol (169 Da, Ligand)
- Slc19a3 (Complex from Homo sapiens)
SLC19A3-Fedratinib outward structure
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8z7u
Q-score: 0.535
Slc19A3-Amprolium outward structure
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8z7v
Q-score: 0.497
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Slc19a3 (Complex from Homo sapiens)
- Amprolium (243 Da, Ligand)
SLC19A3-Metformin outward structure
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8z7w
Q-score: 0.533
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Slc19a3 (Complex from Homo sapiens)
- Metformin (129 Da, Ligand)
SLC19A3-Thiamine inward structure
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8z7x
Q-score: 0.443
SLC19A3-Fedratinib inward structure
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8z7y
Q-score: 0.484
Cryo-EM structure of human apo VMAT2 with nanobody in an outward-facing conformation
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8wlj
Q-score: 0.374
To Be Published
- Nanobody (13 kDa, Protein from Vicugna pacos)
- Nanobody (Complex from Vicugna pacos)
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
- Vesicular monoamine transporter 2 (Complex)
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wlk
Q-score: 0.424
To Be Published