Inward-facing structure of human EAAT2 in the WAY213613-bound state
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7vr7
Q-score: 0.553
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
Nat Commun (2022) 13 pp. 4714-4714 [ DOI: doi:10.1038/s41467-022-32442-6 Pubmed: 35953475 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- (2s)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid (415 Da, Ligand)
- Excitatory amino acid transporter 2 (63 kDa, Protein from Homo sapiens)
- Eaat2 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Inward-facing structure of human EAAT2 in the substrate-free state
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7vr8
Q-score: 0.431
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
Nat Commun (2022) 13 pp. 4714-4714 [ DOI: doi:10.1038/s41467-022-32442-6 Pubmed: 35953475 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Excitatory amino acid transporter 2 (63 kDa, Protein from Homo sapiens)
- Eaat2 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
NPC1-NPC2 complex structure at pH 5.5
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6w5v
Q-score: 0.358
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N
Cell (2020) 182 pp. 98-111.e18 [ DOI: doi:10.1016/j.cell.2020.05.020 Pubmed: 32544384 ]
- Npc intracellular cholesterol transporter 2 (17 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Npc intracellular cholesterol transporter 1 (146 kDa, Protein from Homo sapiens)
- Npc1-npc2 complex at ph 5.5 (170 kDa, Complex from Homo sapiens)
Structure of the rat vesicular glutamate transporter 2 determined by single particle Cryo-EM
Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM
Science (2020) 368 pp. 893-897 [ Pubmed: 32439795 DOI: doi:10.1126/science.aba9202 ]
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 6rvx
Q-score: 0.488
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)
- C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
Inward-open structure of the ASCT2 (SLC1A5) in absence of substrate
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- Asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)
- Asct2 (Protein from Homo sapiens)
Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate
Resolution: 4.13 Å
EM Method: Single-particle
Fitted PDBs: 6rvy
Q-score: 0.369
Garaeva AA, Guskov A, Slotboom DJ, Paulino C
Nat Commun (2019) 10 pp. 3427-3427 [ Pubmed: 31366933 DOI: doi:10.1038/s41467-019-11363-x ]
- Neutral amino acid transporter b(0) (57 kDa, Protein from Homo sapiens)
- C467r mutant of asct2 (alanine serine cysteine transporter 2, slc1a) (172 kDa, Complex from Homo sapiens)