Cryo-EM structure of the human 39S mitoribosome with Tigecycline
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8k2b
Q-score: 0.477
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- 55s mitoribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- 4'-phosphopantetheine (358 Da, Ligand)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Mitochondrial ribosome and complex i assembly factor altmief1 (8 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 39S mitoribosome with 5uM Tigecycline
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xt1
Q-score: 0.472
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human 39S mitoribosome with 10uM Tigecycline
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xt3
Q-score: 0.467
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
Large subunit of the Chlamydomonas reinhardtii mitoribosome
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7pkt
Q-score: 0.486
Waltz F, Salinas-Giege T, Englmeier R, Meichel H, Soufari H, Kuhn L, Pfeffer S, Forster F, Engel BD, Giege P, Drouard L, Hashem Y
Nat Commun (2021) 12 pp. 7176-7176 [ Pubmed: 34887394 DOI: doi:10.1038/s41467-021-27200-z ]
- L4 rrna (38 kDa, RNA from Chlamydomonas reinhardtii)
- Ml41 (12 kDa, Protein from Chlamydomonas reinhardtii)
- Ml59/64 (14 kDa, Protein from Chlamydomonas reinhardtii)
- Ribosomal_l30 domain-containing protein (24 kDa, Protein from Chlamydomonas reinhardtii)
- Ml63/57/60 (14 kDa, Protein from Chlamydomonas reinhardtii)
- L1 rrna (51 kDa, RNA from Chlamydomonas reinhardtii)
- 50s ribosomal protein l9, chloroplastic (30 kDa, Protein from Chlamydomonas reinhardtii)
- Ribosomal_l2_c domain-containing protein (41 kDa, Protein from Chlamydomonas reinhardtii)
- Large subunit of the mitochondrial ribosome of chlamydomonas reinhardtii (Complex from Chlamydomonas reinhardtii)
- Ml114 (48 kDa, Protein from Chlamydomonas reinhardtii)
- Ml119 (36 kDa, Protein from Chlamydomonas reinhardtii)
- Unk2 (4 kDa, Protein from Chlamydomonas reinhardtii)
- Bl35m (17 kDa, Protein from Chlamydomonas reinhardtii)
- Plastid ribosomal protein l6 (22 kDa, Protein from Chlamydomonas reinhardtii)
- Ul14m (13 kDa, Protein from Chlamydomonas reinhardtii)
- Ml118 (64 kDa, Protein from Chlamydomonas reinhardtii)
- Bl21m (40 kDa, Protein from Chlamydomonas reinhardtii)
- Ml80 (27 kDa, Protein from Chlamydomonas reinhardtii)
- Ml115 (72 kDa, Protein from Chlamydomonas reinhardtii)
- Ml116 (53 kDa, Protein from Chlamydomonas reinhardtii)
- Zinc ion (65 Da, Ligand)
- Ul29m (14 kDa, Protein from Chlamydomonas reinhardtii)
- Ml43 (16 kDa, Protein from Chlamydomonas reinhardtii)
- L3b rrna (59 kDa, RNA from Chlamydomonas reinhardtii)
- Ul22m (39 kDa, Protein from Chlamydomonas reinhardtii)
- 50s ribosomal protein l20 (13 kDa, Protein from Chlamydomonas reinhardtii)
- L2a rrna (27 kDa, RNA from Chlamydomonas reinhardtii)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Ul3m (44 kDa, Protein from Chlamydomonas reinhardtii)
- Bl28m (17 kDa, Protein from Chlamydomonas reinhardtii)
- L5 rrna (47 kDa, RNA from Chlamydomonas reinhardtii)
- Mitochondrial ribosomal protein l33 (6 kDa, Protein from Chlamydomonas reinhardtii)
- L8 rrna (132 kDa, RNA from Chlamydomonas reinhardtii)
- Bl34m (29 kDa, Protein from Chlamydomonas reinhardtii)
- Mitochondrial ribosomal protein l23 (25 kDa, Protein from Chlamydomonas reinhardtii)
- Ml117 (75 kDa, Protein from Chlamydomonas reinhardtii)
- Bl36m (3 kDa, Protein from Chlamydomonas reinhardtii)
- L3a rrna (5s) (24 kDa, RNA from Chlamydomonas reinhardtii)
- Mitochondrial ribosomal protein l17,bl17m (21 kDa, Protein from Chlamydomonas reinhardtii)
- L6 rrna (43 kDa, RNA from Chlamydomonas reinhardtii)
- Mitochondrial ribosomal protein l13 (29 kDa, Protein from Chlamydomonas reinhardtii)
- Ul4m (45 kDa, Protein from Chlamydomonas reinhardtii)
- Ml113 (84 kDa, Protein from Chlamydomonas reinhardtii)
- Bl32m (13 kDa, Protein from Chlamydomonas reinhardtii)
- L7 rrna (186 kDa, RNA from Chlamydomonas reinhardtii)
- Unk1 (2 kDa, Protein from Chlamydomonas reinhardtii)
- Ribosomal_l18e/l15p domain-containing protein (35 kDa, Protein from Chlamydomonas reinhardtii)
- Ul5m (23 kDa, Protein from Chlamydomonas reinhardtii)
- Mitochondrial ribosomal protein l17 (27 kDa, Protein from Chlamydomonas reinhardtii)
- Ribosomal_l16 domain-containing protein (27 kDa, Protein from Chlamydomonas reinhardtii)
- Bl27m (18 kDa, Protein from Chlamydomonas reinhardtii)
- Mitochondrial ribosomal protein l19 (33 kDa, Protein from Chlamydomonas reinhardtii)
- Ribosomal_tl5_c domain-containing protein (38 kDa, Protein from Chlamydomonas reinhardtii)
- Ppr* (14 kDa, Protein from Chlamydomonas reinhardtii)
- Kow domain-containing protein,ul24m (31 kDa, Protein from Chlamydomonas reinhardtii)
- Ml40 (17 kDa, Protein from Chlamydomonas reinhardtii)
- Ml87 (23 kDa, Protein from Chlamydomonas reinhardtii)