The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex
Brito Querido J, Sokabe M, Diaz-Lopez I, Gordiyenko Y, Zuber P, Du Y, Albacete-Albacete L, Ramakrishnan V, Fraser CS
Nat Commun (2024) 15 pp. 6633-6633 [ Pubmed: 39117603 DOI: doi:10.1038/s41467-024-50672-8 ]
- Small ribosomal subunit protein es17 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es26 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us19 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es19 (16 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit c (105 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us17 (18 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 1 (12 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es8 (24 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit b (77 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es24 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es10 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es25 (13 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit g (35 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es30 (6 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es1 (30 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es12 (14 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Homo sapiens)
- Rrna (555 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us12 (15 kDa, Protein from Homo sapiens)
- Pdcd4-40s-eif4a-eif3-eif1 complex (2 MDa, Complex from Homo sapiens)
- Small ribosomal subunit protein us9 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Homo sapiens)
- Eukaryotic initiation factor 4a-i (44 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es4, x isoform (29 kDa, Protein from Homo sapiens)
- Programmed cell death protein 4 (52 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Homo sapiens)
- Spermidine (145 Da, Ligand)
- Small ribosomal subunit protein es32 (3 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15 (17 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit d (64 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14 (6 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit f (37 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Acetic acid (60 Da, Ligand)
- Small ribosomal subunit protein es6 (28 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es27 (9 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us4 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es28 (7 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit i (36 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit a (166 kDa, Protein from Homo sapiens)
Mammalian 48S late-stage initiation complex with beta-globin mRNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6yal
Q-score: 0.379
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y
Cell Rep (2020) 31 pp. 107497-107497 [ Pubmed: 32268096 DOI: doi:10.1016/j.celrep.2020.03.061 ]
- 40s ribosomal protein es27 (9 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us17 (18 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us4 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us9 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es19 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es21 (8 kDa, Protein from Oryctolagus cuniculus)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- 40s ribosomal protein es26 (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es4 (29 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es24 (15 kDa, Protein from Oryctolagus cuniculus)
- 18s ribosomal rna (601 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein es1 (29 kDa, Protein from Oryctolagus cuniculus)
- 60s ribosomal protein ul41 (3 kDa, Protein from Oryctolagus cuniculus)
- Atp-binding cassette sub-family e member 1 (abce1) (66 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us5 (24 kDa, Protein from Oryctolagus cuniculus)
- Ls48s ic (Complex from Oryctolagus cuniculus)
- 40s ribosomal protein us7 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es30 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us13 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
- Initiator methionylated trna (24 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein us15 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es8 (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein rack1 (34 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 2 subunit alpha (32 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us12 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es10 (11 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es7 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es28 (7 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us14 (6 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 1a (12 kDa, Protein from Oryctolagus cuniculus)
- Beta-globin mrna (13 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es31 (8 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us2 (23 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es6 (27 kDa, Protein from Oryctolagus cuniculus)
- Ls48s ic with beta-globin mrna (Complex)
- Eukaryotic translation initiation factor 2 subunit gamma (45 kDa, Protein from Oryctolagus cuniculus)
- Iron/sulfur cluster (351 Da, Ligand)
- 40s ribosomal protein us8 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us3 (26 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es12 (14 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es25 (13 kDa, Protein from Oryctolagus cuniculus)
- Beta-globin mrna (Complex from Homo sapiens)
Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6yam
Q-score: 0.257
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y
Cell Rep (2020) 31 pp. 107497-107497 [ Pubmed: 32268096 DOI: doi:10.1016/j.celrep.2020.03.061 ]
- 40s ribosomal protein es27 (9 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us11 (16 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us17 (18 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es25 (8 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es30 (6 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 2 subunit gamma (45 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us2 (23 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us4 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us9 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es17 (15 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es21 (8 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us12 (15 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Oryctolagus cuniculus)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- 40s ribosomal protein es26 (12 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es4 (29 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es24 (15 kDa, Protein from Oryctolagus cuniculus)
- 18s ribosomal rna (601 kDa, RNA from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit a (163 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit d (64 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es1 (29 kDa, Protein from Oryctolagus cuniculus)
- Atp-binding cassette sub-family e member 1 (abce1) (66 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us5 (24 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us13 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us10 (13 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es31 (8 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Oryctolagus cuniculus)
- Initiator methionylated trna (24 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein us3 (25 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us15 (17 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us7 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es8 (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein rack1 (34 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit c (105 kDa, Protein from Oryctolagus cuniculus)
- Beta-globin mrna (14 kDa, RNA from Homo sapiens)
- 40s ribosomal protein es10 (11 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es28 (7 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us14 (6 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es19 (16 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 2 subunit alpha (30 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es7 (21 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 1a (16 kDa, Protein from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l41 (3 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit f (30 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein us19 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es6 (27 kDa, Protein from Oryctolagus cuniculus)
- Ls48s+eif3 ic (Complex from Oryctolagus cuniculus)
- Ls48s+eif3 ic with beta-globin mrna (Complex)
- Iron/sulfur cluster (351 Da, Ligand)
- 40s ribosomal protein us8 (14 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein es12 (14 kDa, Protein from Oryctolagus cuniculus)
- Beta-globin mrna (Complex from Homo sapiens)