Cryo-EM structure of the human ubiquitylated 40S ribosome with RIOK3
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8zdb
Q-score: 0.414
Huang Z, Diehl FF, Wang M, Li Y, Song A, Chen FX, Rosa-Mercado NA, Beckmann R, Green R, Cheng J
Mol Cell (2025) [ Pubmed: 39947183 DOI: doi:10.1016/j.molcel.2025.01.013 ]
- Small ribosomal subunit protein us17 (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9 (16 kDa, Protein from Homo sapiens)
- 18s rrna (602 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein es6 (28 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es30 (6 kDa, Protein from Homo sapiens)
- Ubiquitylated 40s ribosome with riok3 (Complex from Homo sapiens)
- Small ribosomal subunit protein es26 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es10 (18 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase rio3 (59 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es12 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es1 (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14 (6 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us19 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es4, x isoform (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es32 (3 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es8 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es28 (7 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es24 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es25 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es19 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ubiquitin (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us4 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es17 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es27 (9 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8zdc
Q-score: 0.368
Huang Z, Diehl FF, Wang M, Li Y, Song A, Chen FX, Rosa-Mercado NA, Beckmann R, Green R, Cheng J
Mol Cell (2025) [ Pubmed: 39947183 DOI: doi:10.1016/j.molcel.2025.01.013 ]
- Small ribosomal subunit protein us17 (18 kDa, Protein from Homo sapiens)
- Rna-binding protein nob1 (46 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es6 (28 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Homo sapiens)
- Ubiquitylated pre-40s ribosome with riok3 (Complex from Homo sapiens)
- Small ribosomal subunit protein es10 (18 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase rio3 (59 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es12 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es1 (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14 (6 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us19 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es4, x isoform (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Homo sapiens)
- Protein ltv1 homolog (54 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es8 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es28 (7 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es24 (15 kDa, Protein from Homo sapiens)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es25 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es19 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us4 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es17 (15 kDa, Protein from Homo sapiens)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us15 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es27 (9 kDa, Protein from Homo sapiens)
- Rna-binding protein pno1 (27 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human ubiquitylated pre-40S ribosome with RIOK3 (without NOB1)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8zdd
Q-score: 0.396
Huang Z, Diehl FF, Wang M, Li Y, Song A, Chen FX, Rosa-Mercado NA, Beckmann R, Green R, Cheng J
Mol Cell (2025) [ Pubmed: 39947183 DOI: doi:10.1016/j.molcel.2025.01.013 ]
- Small ribosomal subunit protein us17 (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es6 (28 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us13 (17 kDa, Protein from Homo sapiens)
- Ubiquitylated pre-40s ribosome with riok3 (Complex from Homo sapiens)
- Small ribosomal subunit protein es10 (18 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase rio3 (59 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es12 (14 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es1 (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14 (6 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us19 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es4, x isoform (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein rack1 (35 kDa, Protein from Homo sapiens)
- Protein ltv1 homolog (54 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us11 (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es8 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5 (31 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es28 (7 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es24 (15 kDa, Protein from Homo sapiens)
- Pre-rrna-processing protein tsr1 homolog (91 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es25 (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es19 (16 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Small ribosomal subunit protein us2 (32 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us4 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es17 (15 kDa, Protein from Homo sapiens)
- 18s rrna (604 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us15 (17 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es21 (9 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein es27 (9 kDa, Protein from Homo sapiens)
- Rna-binding protein pno1 (27 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8k2d
Q-score: 0.423
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- 40s ribosomal protein s8-a (22 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el39 (6 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us19 (16 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el6a (20 kDa, Protein from Saccharomyces cerevisiae)
- Yeast 80s ribosome (Complex from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el29 (6 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s6-a (27 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es12 (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul22a (20 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el27a (15 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s22-a (14 kDa, Protein from Saccharomyces cerevisiae)
- Suppressor protein stm1 (30 kDa, Protein from Saccharomyces cerevisiae)
- 23s rrna (1 MDa, RNA from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul14a (14 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ul11a (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el18a (20 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el19a (21 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el34a (13 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s27-a (8 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul15 (16 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us13a (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul2a (27 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul23 (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el36a (11 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el14a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el31a (12 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el37a (9 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el21a (18 kDa, Protein from Saccharomyces cerevisiae)
- Eukaryotic translation initiation factor 5a-1 (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul5a (19 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us2a (28 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es19a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el22a (13 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el20a (20 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es10a (12 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s24-a (15 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s2 (27 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s1-a (28 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us9a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul16 (25 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul13a (22 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul29a (13 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein rack1 (34 kDa, Protein from Saccharomyces cerevisiae)
- Ubiquitin-ribosomal protein es31 fusion protein (17 kDa, Protein from Saccharomyces cerevisiae)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Large ribosomal subunit protein ul6a (21 kDa, Protein from Saccharomyces cerevisiae)
- Ubiquitin-ribosomal protein el40a fusion protein (14 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el24a (17 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es21a (9 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el43a (10 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el41a (3 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us17a (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul1a (24 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s9-a (22 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us14a (6 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein es26b (13 kDa, Protein from Saccharomyces cerevisiae)
- 5.8s rrna (50 kDa, RNA from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul4a (39 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el15a (24 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s23-a (16 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el8a (28 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us7 (25 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es25a (12 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el42a (12 kDa, Protein from Saccharomyces cerevisiae)
- 18s rrna (579 kDa, RNA from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el13a (22 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s14-a (14 kDa, Protein from Saccharomyces cerevisiae)
- Elongation factor 2 (93 kDa, Protein from Saccharomyces cerevisiae)
- 5s rrna (38 kDa, RNA from Saccharomyces cerevisiae)
- 40s ribosomal protein s7-a (21 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul30a (27 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el33a (12 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el38 (8 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el30 (11 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul24a (14 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es28a (7 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s30-a (7 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul18 (33 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s4-a (29 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es17a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul3 (43 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el32 (14 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul10 (33 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s13 (17 kDa, Protein from Saccharomyces cerevisiae)
- Tigecycline (587 Da, Ligand)
Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k82
Q-score: 0.453
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- 40s ribosomal protein s8-a (22 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el39 (6 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us19 (16 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el6a (20 kDa, Protein from Saccharomyces cerevisiae)
- Yeast 80s ribosome (Complex from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el29 (6 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s6-a (27 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es12 (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul22a (20 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el27a (15 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s22-a (14 kDa, Protein from Saccharomyces cerevisiae)
- 23s rrna (1 MDa, RNA from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul14a (14 kDa, Protein from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ul11a (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el18a (20 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el19a (21 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el34a (13 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s27-a (8 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul15 (16 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us13a (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul2a (27 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul23 (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el36a (11 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us3 (26 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el14a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el31a (12 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el37a (9 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el21a (18 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul5a (19 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us2a (28 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es19a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el22a (13 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el20a (20 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es10a (12 kDa, Protein from Saccharomyces cerevisiae)
- Spermidine (145 Da, Ligand)
- General negative regulator of transcription subunit 5 (65 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s24-a (15 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s2 (27 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s1-a (28 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us9a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul16 (25 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul13a (22 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul29a (13 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein rack1 (34 kDa, Protein from Saccharomyces cerevisiae)
- Ubiquitin-ribosomal protein es31 fusion protein (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul6a (21 kDa, Protein from Saccharomyces cerevisiae)
- Ubiquitin-ribosomal protein el40a fusion protein (14 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us10 (13 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el24a (17 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es21a (9 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el43a (10 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el41a (3 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us17a (17 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul1a (24 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s9-a (22 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us14a (6 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein es26b (13 kDa, Protein from Saccharomyces cerevisiae)
- 5.8s rrna (50 kDa, RNA from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul4a (39 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el15a (24 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s23-a (16 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el8a (28 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein us7 (25 kDa, Protein from Saccharomyces cerevisiae)
- Trna (24 kDa, RNA from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es25a (12 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el42a (12 kDa, Protein from Saccharomyces cerevisiae)
- 18s rrna (579 kDa, RNA from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el13a (22 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s14-a (14 kDa, Protein from Saccharomyces cerevisiae)
- 5s rrna (38 kDa, RNA from Saccharomyces cerevisiae)
- 40s ribosomal protein s7-a (21 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul30a (27 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el33a (12 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el38 (8 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el30 (11 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul24a (14 kDa, Protein from Saccharomyces cerevisiae)
- Mrna (935 Da, RNA from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es28a (7 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s30-a (7 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul18 (33 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s4-a (29 kDa, Protein from Saccharomyces cerevisiae)
- Small ribosomal subunit protein es17a (15 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul3 (43 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein el32 (14 kDa, Protein from Saccharomyces cerevisiae)
- Large ribosomal subunit protein ul10 (33 kDa, Protein from Saccharomyces cerevisiae)
- 40s ribosomal protein s13 (17 kDa, Protein from Saccharomyces cerevisiae)
- Tigecycline (587 Da, Ligand)
Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xt0
Q-score: 0.434
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms34 (25 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms38 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10m (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms40 (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms39 (78 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5m (48 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms22 (41 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14m (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs16m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms31 (45 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms33 (12 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9m (45 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs21m (10 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15m (29 kDa, Protein from Homo sapiens)
- 12s rrna (306 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us11m (20 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs6m (14 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us17m (14 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Small ribosomal subunit protein ms25 (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms27 (47 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs18m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7m (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms29 (45 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein ms26 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs1m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms23 (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms35 (36 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms37 (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3m (19 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8xt2
Q-score: 0.415
Li X, Wang M, Denk T, Buschauer R, Li Y, Beckmann R, Cheng J
Nat Commun (2024) 15 pp. 5481-5481 [ Pubmed: 38942792 DOI: doi:10.1038/s41467-024-49797-7 ]
- Large ribosomal subunit protein ul23m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml49 (19 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml40 (24 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms34 (25 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms38 (22 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us10m (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul15m (33 kDa, Protein from Homo sapiens)
- Val trna (22 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein ml37 (48 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms40 (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl35m (21 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms39 (78 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml45 (35 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us5m (48 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms22 (41 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl28m (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us14m (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs16m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl32m (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul3m (38 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms31 (45 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml64 (25 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul14m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml65 (50 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul13m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms33 (12 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us12m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml53 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml62 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul11m (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us9m (45 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs21m (10 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us15m (29 kDa, Protein from Homo sapiens)
- 12s rrna (306 kDa, RNA from Homo sapiens)
- Small ribosomal subunit protein us11m (20 kDa, Protein from Homo sapiens)
- 55s ribosome with tigecycline (Complex from Homo sapiens)
- Large ribosomal subunit protein bl17m (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs6m (14 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl36m (11 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul24m (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl21m (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul10m (29 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml63 (12 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml42 (16 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml50 (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us17m (14 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Small ribosomal subunit protein ms25 (20 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms27 (47 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs18m (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- Large ribosomal subunit protein ml41 (15 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us7m (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl20m (17 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl27m (16 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms29 (45 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein ms26 (24 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml46 (31 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml54 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml38 (44 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul4m (34 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl9m (30 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein bs1m (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml48 (23 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml39 (38 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms23 (21 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul16m (28 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml55 (15 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml66 (22 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul29m (29 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms35 (36 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l18, isoform cra_b (20 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us2m (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein bl19m (33 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein ms37 (13 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml44 (37 kDa, Protein from Homo sapiens)
- Small ribosomal subunit protein us3m (19 kDa, Protein from Homo sapiens)
- Tigecycline (587 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7tql
Q-score: 0.412
Lapointe CP, Grosely R, Sokabe M, Alvarado C, Wang J, Montabana E, Villa N, Shin BS, Dever TE, Fraser CS, Fernandez IS, Puglisi JD
Nature (2022) 607 pp. 185-190 [ Pubmed: 35732735 DOI: doi:10.1038/s41586-022-04858-z ]
- Ribosomal protein es25 (8 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (23 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (26 kDa, Protein from Homo sapiens)
- Ribosomal protein us2 (47 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- 40s ribosomal protein s5 (21 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- Ribosomal protein el41 (2 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- Ribosomal protein us10 (11 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (8 kDa, Protein from Homo sapiens)
- Ribosomal protein us14 (6 kDa, Protein from Homo sapiens)
- Human 40s ribosomal subunit in complex with eif1a and eif5b (Cell from Homo sapiens)
- Isoform 3 of 40s ribosomal protein s24 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27a (7 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (24 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 5b (69 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (15 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (34 kDa, Protein from Homo sapiens)
- Ribosomal protein es30 (5 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- Ribosomal protein us11 (14 kDa, Protein from Homo sapiens)
- Ribosomal protein us13 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (11 kDa, Protein from Homo sapiens)
- Ribosomal protein us15 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (11 kDa, Protein from Homo sapiens)
- Ribosomal protein es28 (6 kDa, Protein from Homo sapiens)
- Translation initiation factor eif1a (10 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (21 kDa, Protein from Homo sapiens)
- Ribosomal protein es17 (15 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 18s ribosomal rna (534 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s11 (17 kDa, Protein from Homo sapiens)
- Ribosomal protein es12 (13 kDa, Protein from Homo sapiens)
- Human met-trnaimet (24 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- Guanosine-5'-monophosphate (363 Da, Ligand)
- 40s ribosomal protein s9 (21 kDa, Protein from Homo sapiens)