pP1192R-DNA-m-AMSA complex DNA binding/cleavage domain
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8yge
Q-score: 0.513
Liu R, Sun J, Li LF, Cheng Y, Li M, Fu L, Li S, Peng G, Wang Y, Liu S, Qu X, Ran J, Li X, Pang E, Qiu HJ, Wang Y, Qi J, Wang H, Gao GF
Nucleic Acids Res (2024) 52 pp. 11301-11316 [ Pubmed: 39166497 DOI: doi:10.1093/nar/gkae703 ]
- N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide (393 Da, Ligand)
- Dna topoisomerase 2 (135 kDa, Protein from African swine fever virus pig/Kenya/KEN-50/1950)
- Dna (12-mer) (3 kDa, DNA from African swine fever virus pig/Kenya/KEN-50/1950)
- Dna (8-mer) (2 kDa, DNA from African swine fever virus pig/Kenya/KEN-50/1950)
- Pp1192r-dna-m-amsa complex dna binding/cleavage domain (Complex from African swine fever virus pig/Kenya/KEN-50/1950)
- Magnesium ion (24 Da, Ligand)
- Dna (20-mer) (6 kDa, DNA from African swine fever virus pig/Kenya/KEN-50/1950)
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8vs6
Q-score: 0.577
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ DOI: doi:10.1016/j.cell.2024.08.036 Pubmed: 39288764 ]
- L-tgf-b3/avb8 complex (100 kDa, Complex)
- Magnesium ion (24 Da, Ligand)
- Integrin alpha-v (106 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transforming growth factor beta-3 proprotein (44 kDa, Protein from Homo sapiens)
- Integrin beta-8 (71 kDa, Protein from Homo sapiens)
- L-tgf-b3 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Avb8 complex (Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vsd
Q-score: 0.508
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Integrin alpha-v heavy chain (65 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Transforming growth factor beta activator lrrc32 (61 kDa, Protein from Homo sapiens)
- Avb8/l-tgf-b1/garp complex (180 kDa, Complex from Homo sapiens)
- Integrin beta-8 (39 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Transforming growth factor beta-1 proprotein (41 kDa, Protein from Homo sapiens)
- L-tgf-b1/garp complex (Complex from Homo sapiens)
- Avb8 complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate
Resolution: 7.82 Å
EM Method: Single-particle
Fitted PDBs: 8zc2
Q-score: 0.103
Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X
Cell Rep (2024) 43 pp. 114265-114265 [ Pubmed: 38805396 DOI: doi:10.1016/j.celrep.2024.114265 ]
- Sars-cov-2 omicron ba.2 spike trimer (6p) in complex with d1f6 fab, head-to-head aggregate (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of d1f6 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of d1f6 fab (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, head-to-head aggregate
Resolution: 6.85 Å
EM Method: Single-particle
Fitted PDBs: 8zc6
Q-score: 0.116
Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X
Cell Rep (2024) 43 pp. 114265-114265 [ Pubmed: 38805396 DOI: doi:10.1016/j.celrep.2024.114265 ]
- Light chain of d1f6 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of d1f6 fab (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron ba.4 spike trimer (6p) in complex with d1f6 fab, head-to-head aggregate (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Omicron BA.1 spike trimer (x2-4P) in complex with 3 D1F6 Fabs (0 RBD up)
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8zby
Q-score: 0.372
Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X
Cell Rep (2024) 43 pp. 114265-114265 [ DOI: doi:10.1016/j.celrep.2024.114265 Pubmed: 38805396 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of d1f6 fab (24 kDa, Protein from Homo sapiens)
- Light chain of d1f6 fab (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron ba.1 spike trimer (x2-4p) in complex with 3 d1f6 fabs (0 rbd up) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up)
Resolution: 4.71 Å
EM Method: Single-particle
Fitted PDBs: 8zbz
Q-score: 0.272
Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X
Cell Rep (2024) 43 pp. 114265-114265 [ DOI: doi:10.1016/j.celrep.2024.114265 Pubmed: 38805396 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of d1f6 fab (24 kDa, Protein from Homo sapiens)
- Light chain of d1f6 fab (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron ba.2 spike trimer (6p) in complex with 3 d1f6 fabs (1 rbd up) (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron BA.2 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 8zc0
Q-score: 0.338
Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X
Cell Rep (2024) 43 pp. 114265-114265 [ Pubmed: 38805396 DOI: doi:10.1016/j.celrep.2024.114265 ]
- Light chain of d1f6 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of d1f6 fab (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron ba.2 spike trimer (6p) in complex with 3 d1f6 fabs (2 rbd up) (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (1 RBD up)
Resolution: 4.69 Å
EM Method: Single-particle
Fitted PDBs: 8zc3
Q-score: 0.29
Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X
Cell Rep (2024) 43 pp. 114265-114265 [ Pubmed: 38805396 DOI: doi:10.1016/j.celrep.2024.114265 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron ba.4 spike trimer (6p) in complex with 3 d1f6 fabs (1 rbd up) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of d1f6 fab (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of d1f6 fab (24 kDa, Protein from Homo sapiens)
SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up)
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 8zc4
Q-score: 0.372
Liu B, Niu X, Deng Y, Zhang Z, Wang Y, Gao X, Liang H, Li Z, Wang Q, Cheng Y, Chen Q, Huang S, Pan Y, Su M, Lin X, Niu C, Chen Y, Yang W, Zhang Y, Yan Q, He J, Zhao J, Chen L, Xiong X
Cell Rep (2024) 43 pp. 114265-114265 [ Pubmed: 38805396 DOI: doi:10.1016/j.celrep.2024.114265 ]
- Sars-cov-2 omicron ba.4 spike trimer (6p) in complex with 3 d1f6 fabs (2 rbd up) (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of d1f6 fab (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of d1f6 fab (24 kDa, Protein from Homo sapiens)