Locally refined region of SARS-CoV-2 spike in complex with antibodies 9G11 and 3E2.
Jiang W, Jiang Y, Sun H, Deng T, Yu K, Fang Q, Ge H, Lan M, Lin Y, Fang Z, Zhang Y, Zhou L, Li T, Yu H, Zheng Q, Li S, Xia N, Gu Y
Emerg Microbes Infect (2024) 13 pp. 2406300- [ DOI: doi:10.1038/s41467-023-39265-z Pubmed: 39470577 ]
- Light chain of 3e2 (11 kDa, Protein from Mus)
- Light chain of 9g11 (11 kDa, Protein from Mus)
- Heavy chain of 9g11 (13 kDa, Protein from Mus)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- The fab of 3e2 (Complex from Mus)
- The fab of 9g11 (Complex from Mus)
- Sars-cov-2 spike in complex with antibodies 9g11 and 3e2 (Complex)
- Heavy chain of 3e2 (13 kDa, Protein from Mus)
Cryo-EM structure of human CHT1 in the HC-3 bound outward-facing state
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 9bim
Q-score: 0.472
Human URAT1 bound with Uric acid
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 9jdv
Q-score: 0.344
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Water (18 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- Uric acid (168 Da, Ligand)
- Human uric acid transporter 1 with uric acid (Complex from Homo sapiens)
Human URAT1 bound with verinurad
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9jdy
Q-score: 0.386
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Verinurad (348 Da, Ligand)
- Human uric acid transportor 1 with verinurad (Complex from Homo sapiens)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
Human URAT1 bound to lesinurad
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9jdz
Q-score: 0.361
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Lesinurad (404 Da, Ligand)
- Water (18 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- Human uric acid transportor 1 with lesinurad (Complex from Homo sapiens)
Human URAT1 bound to benzbromarone
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9je0
Q-score: 0.363
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone (424 Da, Ligand)
- Water (18 Da, Ligand)
- Human uric acid transporter 1 with benzbromarone (Complex from Homo sapiens)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
Human URAT1 bound to dotinurad
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9je1
Q-score: 0.359
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Human uric acid transporter 1 with dotinurad (Complex from Homo sapiens)
- Dotinurad (358 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
Cryo-EM structure of the tethered agonist-bound human PAR1-Gq complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xor
Q-score: 0.513
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ DOI: doi:10.1038/s41422-024-00997-2 Pubmed: 38997424 ]
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Gi1-gq chimeric (Complex from Mus musculus)
- Scfv16 (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- Cholesterol (386 Da, Ligand)
- G(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of ligand-bound form of the receptor in complex with the transducer (Complex from Rattus)
- Proteinase-activated receptor 1 (Complex)
Cryo-EM structure of the tethered agonist-bound human PAR1-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xos
Q-score: 0.48
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ DOI: doi:10.1038/s41422-024-00997-2 Pubmed: 38997424 ]
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- Tethered agonist-bound human par1-gi complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (40 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of ACE2-B0AT1 complex with JX98
Xu J, Hu Z, Dai L, Yadav A, Jiang Y, Broer A, Gardiner MG, McLeod M, Yan R, Broer S
Nat Commun (2024) 15 pp. 7224-7224 [ DOI: doi:10.1038/s41467-024-51748-1 Pubmed: 39174516 ]
- Ace2-b0at1 complex with inhibitor jx98 (Complex from Homo sapiens)
- 2-(4-chloranyl-3,5-dimethyl-phenoxy)-~{n}-propan-2-yl-ethanamide (255 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent neutral amino acid transporter b(0)at1 (72 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (94 kDa, Protein from Homo sapiens)