ID BAM37627; SV 1; linear; mRNA; STD; HUM; 3390 BP.
XX
PA AB663645.1
XX
DT 03-SEP-2012 (Rel. 114, Created)
DT 03-SEP-2012 (Rel. 114, Last updated, Version 1)
XX
DE Homo sapiens (human) EML4-ALK fusion protein
XX
KW .
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
XX
RN [1]
RA Mano H., Soda M.;
RT ;
RL Submitted (11-AUG-2011) to the INSDC.
RL Contact:Hiroyuki Mano University of Tokyo, Department of Medical Genomics,
RL Graduate School of Medicine; 7-3-1 Hongo, Bunkyoku, Tokyo 113-0033, Japan
XX
RN [2]
RA Soda M., Isobe K., Inoue A., Maemondo M., Oizumi S., Fujita Y., Gemma A.,
RA Yamashita Y., Ueno T., Takeuchi K., Choi Y., Miyazawa H., Tanaka T.,
RA Hagiwara K., Mano H.;
RT "A prospective PCR-based screening of EML4-ALK oncogene in non-small cell
RT lung cancer";
RL Unpublished.
XX
DR MD5; c39f25b84bdc277b1828ed26a34c3577.
XX
FH Key Location/Qualifiers
FH
FT source 1..3390
FT /organism="Homo sapiens"
FT /mol_type="mRNA"
FT /country="Japan"
FT /cell_type="lung adenocarcinoma"
FT /tissue_type="lung"
FT /db_xref="taxon:9606"
FT CDS AB663645.1:15..3404
FT /codon_start=1
FT /transl_table=1
FT /gene="EML4-ALK"
FT /product="EML4-ALK fusion protein"
FT /db_xref="GOA:J7MA22"
FT /db_xref="InterPro:IPR000719"
FT /db_xref="InterPro:IPR001245"
FT /db_xref="InterPro:IPR001680"
FT /db_xref="InterPro:IPR002011"
FT /db_xref="InterPro:IPR005108"
FT /db_xref="InterPro:IPR008266"
FT /db_xref="InterPro:IPR011009"
FT /db_xref="InterPro:IPR015943"
FT /db_xref="InterPro:IPR017441"
FT /db_xref="InterPro:IPR017986"
FT /db_xref="InterPro:IPR020635"
FT /db_xref="InterPro:IPR036322"
FT /db_xref="UniProtKB/TrEMBL:J7MA22"
FT /protein_id="BAM37627.1"
FT /translation="MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAAL
FT ADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGK
FT ETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPES
FT KNATPTKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQ
FT EGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPT
FT GEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQ
FT PHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQRK
FT AKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKF
FT VQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQ
FT MRNGMLLTGGGKDRKIILWDHDLNPEREIEFSASRARLPGHVAADHPPAVYRRKHQELQ
FT AMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGA
FT FGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGV
FT SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENH
FT FIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFME
FT GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIM
FT TQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGV
FT PPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAF
FT SQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSC
FT TVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATA
FT PGAGHYEDTILKSKNSMNQPGP"
XX
SQ Sequence 3390 BP; 976 A; 835 C; 828 G; 751 T; 0 other;
atggacggtt tcgccggcag tctcgatgat agtatttctg ctgcaagtac ttctgatgtt 60
caagatcgcc tgtcagctct tgagtcacga gttcagcaac aagaagatga aatcactgtg 120
ctaaaggcgg ctttggctga tgttttgagg cgtcttgcaa tctctgaaga tcatgtggcc 180
tcagtgaaaa aatcagtctc aagtaaaggc caaccaagcc ctcgagcagt tattcccatg 240
tcctgtataa ccaatggaag tggtgcaaac agaaaaccaa gtcataccag tgctgtctca 300
attgcaggaa aagaaactct ttcatctgct gctaaaagtg gtacagaaaa aaagaaagaa 360
aaaccacaag gacagagaga aaaaaaagag gaatctcatt ctaatgatca aagtccacaa 420
attcgagcat caccttctcc ccagccctct tcacaacctc tccaaataca cagacaaact 480
ccagaaagca agaatgctac tcccaccaaa agcataaaac gaccatcacc agctgaaaag 540
tcacataatt cttgggaaaa ttcagatgat agccgtaata aattgtcgaa aataccttca 600
acacccaaat taataccaaa agttaccaaa actgcagaca agcataaaga tgtcatcatc 660
aaccaagaag gagaatatat taaaatgttt atgcgcggtc ggccaattac catgttcatt 720
ccttccgatg ttgacaacta tgatgacatc agaacggaac tgcctcctga gaagctcaaa 780
ctggagtggg catatggtta tcgaggaaag gactgtagag ctaatgttta ccttcttccg 840
accggggaaa tagtttattt cattgcatca gtagtagtac tatttaatta tgaggagaga 900
actcagcgac actacctggg ccatacagac tgtgtgaaat gccttgctat acatcctgac 960
aaaattagga ttgcaactgg acagatagct ggcgtggata aagatggaag gcctctacaa 1020
ccccacgtca gagtgtggga ttctgttact ctatccacac tgcagattat tggacttggc 1080
acttttgagc gtggagtagg atgcctggat ttttcaaaag cagattcagg tgttcattta 1140
tgtgttattg atgactccaa tgagcatatg cttactgtat gggactggca gaggaaagca 1200
aaaggagcag aaataaagac aacaaatgaa gttgttttgg ctgtggagtt tcacccaaca 1260
gatgcaaata ccataattac atgcggtaaa tctcatattt tcttctggac ctggagcggc 1320
aattcactaa caagaaaaca gggaattttt gggaaatatg aaaagccaaa atttgtgcag 1380
tgtttagcat tcttggggaa tggagatgtt cttactggag actcaggtgg agtcatgctt 1440
atatggagca aaactactgt agagcccaca cctgggaaag gacctaaagg tgtatatcaa 1500
atcagcaaac aaatcaaagc tcatgatggc agtgtgttca cactttgtca gatgagaaat 1560
gggatgttat taactggagg agggaaagac agaaaaataa ttctgtggga tcatgatctg 1620
aatcctgaaa gagaaataga gtttagtgct tcaagggcca ggctgccagg ccatgttgca 1680
gctgaccacc cacctgcagt gtaccgccgg aagcaccagg agctgcaagc catgcagatg 1740
gagctgcaga gccctgagta caagctgagc aagctccgca cctcgaccat catgaccgac 1800
tacaacccca actactgctt tgctggcaag acctcctcca tcagtgacct gaaggaggtg 1860
ccgcggaaaa acatcaccct cattcggggt ctgggccatg gcgcctttgg ggaggtgtat 1920
gaaggccagg tgtccggaat gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg 1980
ctgcctgaag tgtgctctga acaggacgaa ctggatttcc tcatggaagc cctgatcatc 2040
agcaaattca accaccagaa cattgttcgc tgcattgggg tgagcctgca atccctgccc 2100
cggttcatcc tgctggagct catggcgggg ggagacctca agtccttcct ccgagagacc 2160
cgccctcgcc cgagccagcc ctcctccctg gccatgctgg accttctgca cgtggctcgg 2220
gacattgcct gtggctgtca gtatttggag gaaaaccact tcatccaccg agacattgct 2280
gccagaaact gcctcttgac ctgtccaggc cctggaagag tggccaagat tggagacttc 2340
gggatggccc gagacatcta cagggcgagc tactatagaa agggaggctg tgccatgctg 2400
ccagttaagt ggatgccccc agaggccttc atggaaggaa tattcacttc taaaacagac 2460
acatggtcct ttggagtgct gctatgggaa atcttttctc ttggatatat gccatacccc 2520
agcaaaagca accaggaagt tctggagttt gtcaccagtg gaggccggat ggacccaccc 2580
aagaactgcc ctgggcctgt ataccggata atgactcagt gctggcaaca tcagcctgaa 2640
gacaggccca actttgccat cattttggag aggattgaat actgcaccca ggacccggat 2700
gtaatcaaca ccgctttgcc gatagaatat ggtccacttg tggaagagga agagaaagtg 2760
cctgtgaggc ccaaggaccc tgagggggtt cctcctctcc tggtctctca acaggcaaaa 2820
cgggaggagg agcgcagccc agctgcccca ccacctctgc ctaccacctc ctctggcaag 2880
gctgcaaaga aacccacagc tgcagagatc tctgttcgag tccctagagg gccggccgtg 2940
gaagggggac acgtgaatat ggcattctct cagtccaacc ctccttcgga gttgcacaag 3000
gtccacggat ccagaaacaa gcccaccagc ttgtggaacc caacgtacgg ctcctggttt 3060
acagagaaac ccaccaaaaa gaataatcct atagcaaaga aggagccaca cgacaggggt 3120
aacctggggc tggagggaag ctgtactgtc ccacctaacg ttgcaactgg gagacttccg 3180
ggggcctcac tgctcctaga gccctcttcg ctgactgcca atatgaagga ggtacctctg 3240
ttcaggctac gtcacttccc ttgtgggaat gtcaattacg gctaccagca acagggcttg 3300
cccttagaag ccgctactgc ccctggagct ggtcattacg aggataccat tctgaaaagc 3360
aagaatagca tgaaccagcc tgggccctga 3390
//