This study is about the identification of the main AMC resistance mechanism from multiple clinical isolates of C. jejuni and C. coli. In total, 4 C. coli isolated between 2017 and 2021 showed resistance to AMC and AMP, 6 C. coli were resistant to AMP and 4 C. coli were fully susceptible. A total of 11 AMP-R/AMC-S and 10 AMP-S/AMC-S C. jejuni clinical isolates were also selected.