colorectal cancer. Patients with LS have a high lifetime risk for

cancer and an early onset of tumorigenesis. In this study we wanted to

assess the role of the chemopreventive target Nrf2 in LS. Upon

deletion of Nrf2 in a mouse model of LS (MSH2 loxP/loxPVil-cre) we

observed a strong reduction of the tumor incidence in the small

intestine. Nrf2 deficiency was also associated with an increase in

bacterial diversity in this mouse model of LS. Sequencing was performed at the Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna under the project IDs JMF-2011-3 and JMF-2107-04.