To explore the effect of Bicd2 in ConA-induced acute autoimmune hepatitis, we conducted RNA transcriptome profiling of plko-scramble or shBicd2 plasmid hydrodynamic-injected mice livers in response to ConA injection. Overall design: We delivered plko-scramble or shBicd2 plasmid by hydrodynamic injection to 8w wild-type C57BL/6J mice. After 3 days, mice were injected with 15mg/kg ConA i.v and 6 hours later livers were collected to perform RNA sequecing.