To investigate the effect of adipose tissue-specific overexpression of adrenomedullin 2 on the regulation of adipocyte function, the transgenic mouse line with adipocyte-specific overexpression of the ADM2 gene (aADM2-tg mice) was generated on a C57BL/6J background with the human ADM2 gene driven by the adiponectin (Adipoq) gene promoter (H11-Adipoq-hADM2-Wpre-PolyA mice, Strain NO. T059304). The mice were purchased from GemPharmatech (Nanjing, China). We then performed gene expression profiling analysis using data obtained from RNA-seg of visceral adipose tissue from aADM2-Tg and WT group. Overall design: We performed gene expression profiling analysis using data obtained from RNA-seg of visceral adipose tissue from 5 mice per group. Comparative gene expression profiling analysis of RNA-seg data for aADM2-Tg and WT group.