Time-series transcriptomic data of ZFE exposed to the angiogenesis inhibitor SU4312 with exposure start time points at 0 hpf and 24 hpf. Overall design: Wild-type adult zebrafish (D. rerio, strain OBI/WIK, generation F3) were kept at 26°C in 20 L aquaria with 1-2 fish/L, fed twice a day and on a 14h:10h light dark cycle. Eggs were collected within 1h of spawning, fertilized and normally developed eggs were selected and incubated at 26°C. Eggs for the 24 hpf exposure were stored for at 26°C with 50 eggs per 100 mL of ISO-water, shaken at 75 rpm. Eggs were exposed at 2 hpf or at 24 hpf. 10 embryos were incubated in 4 mL of treatment or control solution for the desired exposure time in 6 mL covered GC vials. Incubation was done at 26°C in a 12h:12h light dark cycle and shaken at 75 rpm. Two vials were pooled as one replicate (total of 20 embryos); control data points have two replicates, treatment data points have one replicate.For the 0 hpf exposure there are 10 time points (3, 6, 12, 24, 27, 30, 36, 48, 72 and 96 hpf) and for the 24 hpf exposure there are 6 time points (27, 30, 36, 48, 72 and 96 hpf). In addition to controls, two concentrations were measured for each exposure scenario: 1 and 2 µM in the 0 hpf exposure and 2 and 5 µM in the 24 hpf exposure.