Muscle tissue samples were obtained from severely obese individuals that underwent bariatric surgery. The goal of this study was to identify tissue specific methylation QTLs. Whole-transcriptome subcutaneous adipose tissue methylation levels were determined in 60 individuals with a BMI >35 kg/m2. Overall design: Bisulphite converted DNA from the 60 muscle samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip.